240172

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2506750..2507273 Replicon chromosome
Accession NZ_CP094750
Organism Staphylococcus aureus strain IVB6248

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag MUA07_RS12405 Protein ID WP_000074048.1
Coordinates 2506750..2507016 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA07_RS12410 Protein ID WP_252549875.1
Coordinates 2507016..2507273 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA07_RS12385 (MUA07_12385) 2501969..2503156 - 1188 WP_000026189.1 MFS transporter -
MUA07_RS12390 (MUA07_12390) 2503551..2504327 - 777 WP_000072151.1 iron export ABC transporter permease subunit FetB -
MUA07_RS12395 (MUA07_12395) 2504320..2504982 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
MUA07_RS12400 (MUA07_12400) 2505327..2506394 - 1068 WP_001076685.1 M42 family metallopeptidase -
MUA07_RS12405 (MUA07_12405) 2506750..2507016 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
MUA07_RS12410 (MUA07_12410) 2507016..2507273 - 258 WP_252549875.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA07_RS12415 (MUA07_12415) 2507633..2508088 + 456 WP_000732082.1 DUF1307 domain-containing protein -
MUA07_RS12420 (MUA07_12420) 2508256..2509833 - 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
MUA07_RS12425 (MUA07_12425) 2510027..2510776 + 750 WP_000072456.1 CPBP family lipoprotein N-acylation protein LnsB -
MUA07_RS12430 (MUA07_12430) 2511000..2512193 - 1194 WP_252549877.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T240172 WP_000074048.1 NZ_CP094750:c2507016-2506750 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T240172 NZ_LS992171:648271-648585 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9748.69 Da        Isoelectric Point: 4.0717

>AT240172 WP_252549875.1 NZ_CP094750:c2507273-2507016 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNDNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT240172 NZ_LS992171:648582-648998 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure

References