Detailed information of TA system TA240169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2450067..2450584
• Replicon: chromosome
• Accession: NZ_CP094750
• Organism: Staphylococcus aureus strain IVB6248

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MUA07_RS12130
• Protein ID: WP_000113260.1
• Coordinates: 2450067..2450333 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: MUA07_RS12135
• Protein ID: WP_000584499.1
• Coordinates: 2450333..2450584 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA07_RS12100 (MUA07_12100)	2445219..2445755	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
MUA07_RS12105 (MUA07_12105)	2446277..2447101	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
MUA07_RS12110 (MUA07_12110)	2447304..2447486	-	183	WP_000079140.1	hypothetical protein	-
MUA07_RS12115 (MUA07_12115)	2447573..2448040	-	468	WP_000153340.1	SRPBCC domain-containing protein	-
MUA07_RS12120 (MUA07_12120)	2448226..2449773	-	1548	WP_000727756.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MUA07_RS12125 (MUA07_12125)	2449952..2450032	-	81	WP_225539491.1	hypothetical protein	-
MUA07_RS12130 (MUA07_12130)	2450067..2450333	-	267	WP_000113260.1	Txe/YoeB family addiction module toxin	Toxin
MUA07_RS12135 (MUA07_12135)	2450333..2450584	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MUA07_RS12140 (MUA07_12140)	2450749..2450829	-	81	WP_225539489.1	hypothetical protein	-
MUA07_RS12145 (MUA07_12145)	2450857..2451456	-	600	WP_000162810.1	DsbA family protein	-
MUA07_RS12150 (MUA07_12150)	2451475..2451837	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MUA07_RS12155 (MUA07_12155)	2452092..2453342	+	1251	WP_262541930.1	FemA/FemB family glycyltransferase FmhA	-
MUA07_RS12160 (MUA07_12160)	2453439..2454170	-	732	WP_262541931.1	amino acid ABC transporter ATP-binding protein	-
MUA07_RS12165 (MUA07_12165)	2454167..2454886	-	720	WP_000479579.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.99 Da
• Isoelectric Point: 10.0373

>T240169 WP_000113260.1 NZ_CP094750:c2450333-2450067 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T240169 NZ_LS992170:32163-32414 [Escherichia coli]
ATGAGAAAAAATAAAGGTGATGTGACTTATTTTCTTGAAAAAGAAGGTGACAATTACAGGCTTACAAAAAGGATAAAAGC
CAGAACAAATGTTAAAATCGGGAACAAAACTACGAAAATTACATTGTATGATGCCGTACTGAATGAGAATGAATTACAAC
ATATTGATTTTACGTGTGCCGGATTAAGGGAAGACGATGAGACGCCAGTTAAGAATTTAATTAAGGAGTTTATGTTAAAT
GAAACCCGATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT240169 WP_000584499.1 NZ_CP094750:c2450584-2450333 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT240169 NZ_LS992170:32401-32628 [Escherichia coli]
ATGAAACCCGATAATACACCTGAAAATGTAAAAAAATTACGTTTAAAAGCAGGATTAACACAAAAGGAATGCAGTCATAT
TTATGGTGTTGGGCTAAGAACCTGGCAGAAAAAAGAGGAAGTTAATACTCAAAACAGTCAAAGTCTGTCACTGGTTGAGT
TTGAGTTTCTTTTGTTACTTGCAGGAGAACATCCTGAATACGTGCTCTGCAAAAGGGAGTCAAAATAA

Structures

Antitoxin

• AlphaFold DB: T1YB60