Detailed information of TA system TA240162

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1583086..1583665
• Replicon: chromosome
• Accession: NZ_CP094750
• Organism: Staphylococcus aureus strain IVB6248

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUA07_RS07605
• Protein ID: WP_001025401.1
• Coordinates: 1583420..1583665 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1583086..1583451 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA07_RS07565 (MUA07_07565)	1579828..1580385	-	558	WP_000645049.1	DUF2815 family protein	-
MUA07_RS07570 (MUA07_07570)	1580412..1581578	-	1167	WP_262541838.1	DUF2800 domain-containing protein	-
MUA07_RS07575 (MUA07_07575)	1581575..1581937	-	363	WP_000985986.1	hypothetical protein	-
MUA07_RS07580 (MUA07_07580)	1581952..1582275	-	324	WP_000175000.1	hypothetical protein	-
MUA07_RS07585 (MUA07_07585)	1582354..1582515	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
MUA07_RS07590 (MUA07_07590)	1582528..1582791	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
MUA07_RS07595 (MUA07_07595)	1582816..1583031	-	216	WP_001097552.1	hypothetical protein	-
MUA07_RS07600 (MUA07_07600)	1583086..1583451	+	366	WP_001128433.1	hypothetical protein	Antitoxin
MUA07_RS07605 (MUA07_07605)	1583420..1583665	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUA07_RS07610 (MUA07_07610)	1583681..1583929	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
MUA07_RS07615 (MUA07_07615)	1584093..1584416	+	324	WP_001260486.1	helix-turn-helix transcriptional regulator	-
MUA07_RS07620 (MUA07_07620)	1584429..1584890	+	462	WP_262541840.1	toxin	-
MUA07_RS07625 (MUA07_07625)	1584908..1585342	+	435	WP_031903825.1	hypothetical protein	-
MUA07_RS07630 (MUA07_07630)	1585370..1585765	+	396	WP_001558060.1	hypothetical protein	-
MUA07_RS07635 (MUA07_07635)	1585873..1586064	+	192	WP_252559444.1	hypothetical protein	-
MUA07_RS07640 (MUA07_07640)	1586061..1586639	-	579	WP_252559441.1	hypothetical protein	-
MUA07_RS07645 (MUA07_07645)	1586765..1587970	+	1206	WP_000264747.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541295..1600726	59431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240162 WP_001025401.1 NZ_CP094750:c1583665-1583420 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240162 NZ_LS992168:c4402500-4402150 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240162 NZ_CP094750:1583086-1583451 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin