240160

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 348110..348524 Replicon chromosome
Accession NZ_CP094750
Organism Staphylococcus aureus strain IVB6248

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA07_RS01565 Protein ID WP_110166336.1
Coordinates 348110..348361 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA07_RS01570 Protein ID WP_000028424.1
Coordinates 348351..348524 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA07_RS01500 (MUA07_01500) 343274..344059 + 786 WP_262542124.1 ATP-binding protein -
MUA07_RS01505 (MUA07_01505) 344056..344216 + 161 Protein_298 hypothetical protein -
MUA07_RS01510 (MUA07_01510) 344229..344450 + 222 WP_001123695.1 DUF3269 family protein -
MUA07_RS01515 (MUA07_01515) 344461..344865 + 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA07_RS01520 (MUA07_01520) 344870..345055 + 186 WP_001187242.1 DUF3113 family protein -
MUA07_RS01525 (MUA07_01525) 345056..345673 + 618 WP_262529389.1 SA1788 family PVL leukocidin-associated protein -
MUA07_RS01530 (MUA07_01530) 345673..345930 + 258 WP_031864864.1 DUF3310 domain-containing protein -
MUA07_RS01535 (MUA07_01535) 345933..346133 + 201 WP_252549766.1 hypothetical protein -
MUA07_RS01540 (MUA07_01540) 346130..346819 + 690 WP_252549763.1 N-6 DNA methylase -
MUA07_RS01545 (MUA07_01545) 346833..347039 + 207 WP_252549760.1 hypothetical protein -
MUA07_RS01550 (MUA07_01550) 347067..347468 + 402 WP_262542127.1 hypothetical protein -
MUA07_RS01555 (MUA07_01555) 347465..347812 + 348 WP_252570428.1 YopX family protein -
MUA07_RS01560 (MUA07_01560) 347809..348030 + 222 Protein_309 hypothetical protein -
MUA07_RS01565 (MUA07_01565) 348110..348361 + 252 WP_110166336.1 DUF1024 family protein Toxin
MUA07_RS01570 (MUA07_01570) 348351..348524 + 174 WP_000028424.1 hypothetical protein Antitoxin
MUA07_RS01575 (MUA07_01575) 348525..348806 + 282 WP_000454994.1 hypothetical protein -
MUA07_RS01580 (MUA07_01580) 348807..348968 + 162 WP_000889683.1 hypothetical protein -
MUA07_RS01585 (MUA07_01585) 348983..349516 + 534 WP_025920701.1 dUTP diphosphatase -
MUA07_RS01590 (MUA07_01590) 349553..349759 + 207 WP_033859700.1 DUF1381 domain-containing protein -
MUA07_RS01595 (MUA07_01595) 349756..349905 + 150 WP_000595265.1 transcriptional activator RinB -
MUA07_RS01600 (MUA07_01600) 349905..350105 + 201 WP_111761860.1 DUF1514 family protein -
MUA07_RS01605 (MUA07_01605) 350128..350589 + 462 WP_086037675.1 hypothetical protein -
MUA07_RS01610 (MUA07_01610) 350704..351156 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA07_RS01615 (MUA07_01615) 351172..351516 + 345 WP_000817289.1 HNH endonuclease -
MUA07_RS01620 (MUA07_01620) 351645..352115 + 471 WP_262542129.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 332441..373874 41433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9445.35 Da        Isoelectric Point: 3.9476

>T240160 WP_110166336.1 NZ_CP094750:348110-348361 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240160 NZ_LS992168:4269890-4270147 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240160 WP_000028424.1 NZ_CP094750:348351-348524 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240160 NZ_LS992168:4270159-4270710 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References