Detailed information of TA system TA240158

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2535209..2535393
• Replicon: chromosome
• Accession: NZ_CP094747
• Organism: Staphylococcus aureus strain IVB6249

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA08_RS12775
• Protein ID: WP_000482647.1
• Coordinates: 2535286..2535393 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2535209..2535269 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA08_RS12760 (MUA08_12760)	2530719..2530886	-	168	Protein_2470	hypothetical protein	-
MUA08_RS12765 (MUA08_12765)	2531117..2532850	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
MUA08_RS12770 (MUA08_12770)	2532875..2534638	-	1764	WP_001064829.1	ABC transporter ATP-binding protein	-
-	2535209..2535269	+	61	-	-	Antitoxin
MUA08_RS12775 (MUA08_12775)	2535286..2535393	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA08_RS12780 (MUA08_12780)	2535527..2535913	-	387	WP_000779351.1	flippase GtxA	-
MUA08_RS12785 (MUA08_12785)	2536181..2537323	+	1143	WP_001176855.1	glycerate kinase	-
MUA08_RS12790 (MUA08_12790)	2537383..2538042	+	660	WP_000831298.1	membrane protein	-
MUA08_RS12795 (MUA08_12795)	2538224..2539435	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
MUA08_RS12800 (MUA08_12800)	2539558..2540031	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240158 WP_000482647.1 NZ_CP094747:c2535393-2535286 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240158 NZ_LS992168:c4110751-4110467 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240158 NZ_CP094747:2535209-2535269 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin