Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1957434..1957614 Replicon chromosome
Accession NZ_CP094747
Organism Staphylococcus aureus strain IVB6249

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag MUA08_RS09655 Protein ID WP_001801861.1
Coordinates 1957434..1957529 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1957557..1957614 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA08_RS09630 (MUA08_09630) 1952482..1953849 - 1368 WP_001093574.1 FRG domain-containing protein -
MUA08_RS09635 (MUA08_09635) 1953849..1954265 - 417 WP_262628334.1 ImmA/IrrE family metallo-endopeptidase -
MUA08_RS09640 (MUA08_09640) 1954273..1955919 - 1647 WP_000277741.1 IS1182-like element ISSau3 family transposase -
MUA08_RS09645 (MUA08_09645) 1956162..1956344 - 183 WP_262518259.1 hypothetical protein -
MUA08_RS09650 (MUA08_09650) 1956537..1956983 - 447 WP_000747804.1 DUF1433 domain-containing protein -
MUA08_RS09655 (MUA08_09655) 1957434..1957529 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1957557..1957614 - 58 - - Antitoxin
MUA08_RS09660 (MUA08_09660) 1957652..1957753 + 102 WP_001791232.1 hypothetical protein -
MUA08_RS09665 (MUA08_09665) 1957928..1958371 - 444 WP_001037039.1 DUF1433 domain-containing protein -
MUA08_RS09670 (MUA08_09670) 1958371..1958814 - 444 WP_000731421.1 DUF1433 domain-containing protein -
MUA08_RS09675 (MUA08_09675) 1958814..1959256 - 443 Protein_1905 DUF1433 domain-containing protein -
MUA08_RS09680 (MUA08_09680) 1959781..1962201 + 2421 WP_252559462.1 polysaccharide lyase 8 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1954273..1955919 1646


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T240152 WP_001801861.1 NZ_CP094747:1957434-1957529 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T240152 NZ_LS992168:2159817-2159919 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 58 bp

>AT240152 NZ_CP094747:c1957614-1957557 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References