Detailed information of TA system TA240146

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2521562..2521746
• Replicon: chromosome
• Accession: NZ_CP094745
• Organism: Staphylococcus aureus strain IVB6250

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: MUA64_RS12670
• Protein ID: WP_000482647.1
• Coordinates: 2521639..2521746 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2521562..2521622 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA64_RS12655 (MUA64_12655)	2517072..2517239	-	168	Protein_2449	hypothetical protein	-
MUA64_RS12660 (MUA64_12660)	2517470..2519203	-	1734	WP_000486505.1	ABC transporter ATP-binding protein	-
MUA64_RS12665 (MUA64_12665)	2519228..2520991	-	1764	WP_262518354.1	ABC transporter ATP-binding protein	-
-	2521562..2521622	+	61	-	-	Antitoxin
MUA64_RS12670 (MUA64_12670)	2521639..2521746	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
MUA64_RS12675 (MUA64_12675)	2521880..2522266	-	387	WP_000779351.1	flippase GtxA	-
MUA64_RS12680 (MUA64_12680)	2522534..2523676	+	1143	WP_001176855.1	glycerate kinase	-
MUA64_RS12685 (MUA64_12685)	2523736..2524395	+	660	WP_000831298.1	membrane protein	-
MUA64_RS12690 (MUA64_12690)	2524577..2525788	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
MUA64_RS12695 (MUA64_12695)	2525911..2526384	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T240146 WP_000482647.1 NZ_CP094745:c2521746-2521639 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T240146 NZ_LS992168:641280-641594 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT240146 NZ_CP094745:2521562-2521622 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin