Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2496261..2496778 | Replicon | chromosome |
| Accession | NZ_CP094745 | ||
| Organism | Staphylococcus aureus strain IVB6250 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A170NWK0 |
| Locus tag | MUA64_RS12535 | Protein ID | WP_000251928.1 |
| Coordinates | 2496261..2496527 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | A0A166LMC5 |
| Locus tag | MUA64_RS12540 | Protein ID | WP_000584497.1 |
| Coordinates | 2496527..2496778 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA64_RS12510 (MUA64_12510) | 2491468..2492004 | - | 537 | WP_000024292.1 | GNAT family N-acetyltransferase | - |
| MUA64_RS12515 (MUA64_12515) | 2492472..2493296 | - | 825 | WP_000594640.1 | formate/nitrite transporter family protein | - |
| MUA64_RS12520 (MUA64_12520) | 2493499..2493681 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| MUA64_RS12525 (MUA64_12525) | 2493768..2494235 | - | 468 | WP_250396336.1 | SRPBCC domain-containing protein | - |
| MUA64_RS12530 (MUA64_12530) | 2494421..2495968 | - | 1548 | WP_045179540.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MUA64_RS12535 (MUA64_12535) | 2496261..2496527 | - | 267 | WP_000251928.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUA64_RS12540 (MUA64_12540) | 2496527..2496778 | - | 252 | WP_000584497.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUA64_RS12545 (MUA64_12545) | 2496942..2497042 | - | 101 | Protein_2427 | hypothetical protein | - |
| MUA64_RS12550 (MUA64_12550) | 2497049..2497648 | - | 600 | WP_000162804.1 | DsbA family protein | - |
| MUA64_RS12555 (MUA64_12555) | 2497667..2498029 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MUA64_RS12560 (MUA64_12560) | 2498284..2499534 | + | 1251 | WP_001012237.1 | FemA/FemB family glycyltransferase FmhA | - |
| MUA64_RS12565 (MUA64_12565) | 2499631..2500362 | - | 732 | WP_000615467.1 | amino acid ABC transporter ATP-binding protein | - |
| MUA64_RS12570 (MUA64_12570) | 2500359..2501078 | - | 720 | WP_000479573.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10465.06 Da Isoelectric Point: 10.1628
>T240145 WP_000251928.1 NZ_CP094745:c2496527-2496261 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T240145 NZ_LS992168:c599964-599500 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9401.54 Da Isoelectric Point: 4.3407
>AT240145 WP_000584497.1 NZ_CP094745:c2496778-2496527 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV
Download Length: 252 bp
>AT240145 NZ_LS992168:c600299-599964 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAT
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A170NWK0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A166LMC5 |