Detailed information of TA system TA240140

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1943873..1944053
• Replicon: chromosome
• Accession: NZ_CP094745
• Organism: Staphylococcus aureus strain IVB6250

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MUA64_RS09555
• Protein ID: WP_001801861.1
• Coordinates: 1943873..1943968 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1943996..1944053 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA64_RS09530 (MUA64_09530)	1938921..1940288	-	1368	WP_001093574.1	FRG domain-containing protein	-
MUA64_RS09535 (MUA64_09535)	1940288..1940719	-	432	WP_262518258.1	ImmA/IrrE family metallo-endopeptidase	-
MUA64_RS09540 (MUA64_09540)	1940712..1942358	-	1647	WP_000277741.1	IS1182-like element ISSau3 family transposase	-
MUA64_RS09545 (MUA64_09545)	1942601..1942783	-	183	WP_262518259.1	hypothetical protein	-
MUA64_RS09550 (MUA64_09550)	1942976..1943422	-	447	WP_000747804.1	DUF1433 domain-containing protein	-
MUA64_RS09555 (MUA64_09555)	1943873..1943968	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1943996..1944053	-	58	-	-	Antitoxin
MUA64_RS09560 (MUA64_09560)	1944091..1944192	+	102	WP_001791232.1	hypothetical protein	-
MUA64_RS09565 (MUA64_09565)	1944367..1944810	-	444	WP_001037039.1	DUF1433 domain-containing protein	-
MUA64_RS09570 (MUA64_09570)	1944810..1945253	-	444	WP_000731421.1	DUF1433 domain-containing protein	-
MUA64_RS09575 (MUA64_09575)	1945253..1945695	-	443	Protein_1885	DUF1433 domain-containing protein	-
MUA64_RS09580 (MUA64_09580)	1946220..1948640	+	2421	WP_252559462.1	polysaccharide lyase 8 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hysA / selk	1934530..1973817	39287
	-	flank	IS/Tn	-	-	1940712..1942358	1646

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T240140 WP_001801861.1 NZ_CP094745:1943873-1943968 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T240140 NZ_LS992167:c98565-98284 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGAT
AGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAACCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGAGTATTGCATACTGTACAGAAGTGGCCATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT240140 NZ_CP094745:c1944053-1943996 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin