Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2475304..2475488 Replicon chromosome
Accession NZ_CP094743
Organism Staphylococcus aureus strain IVB6252

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag MUA62_RS12265 Protein ID WP_000482647.1
Coordinates 2475381..2475488 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2475304..2475364 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA62_RS12250 (MUA62_12250) 2470758..2470925 - 168 WP_031927726.1 hypothetical protein -
MUA62_RS12255 (MUA62_12255) 2471156..2472889 - 1734 WP_000486497.1 ABC transporter ATP-binding protein -
MUA62_RS12260 (MUA62_12260) 2472914..2474677 - 1764 WP_252549861.1 ABC transporter ATP-binding protein -
- 2475304..2475364 + 61 - - Antitoxin
MUA62_RS12265 (MUA62_12265) 2475381..2475488 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
MUA62_RS12270 (MUA62_12270) 2475622..2476008 - 387 WP_000779353.1 flippase GtxA -
MUA62_RS12275 (MUA62_12275) 2476276..2477418 + 1143 WP_262541936.1 glycerate kinase -
MUA62_RS12280 (MUA62_12280) 2477478..2478137 + 660 WP_000831298.1 membrane protein -
MUA62_RS12285 (MUA62_12285) 2478320..2479531 + 1212 WP_001191927.1 multidrug effflux MFS transporter -
MUA62_RS12290 (MUA62_12290) 2479654..2480127 - 474 WP_000456493.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T240133 WP_000482647.1 NZ_CP094743:c2475488-2475381 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T240133 NZ_LS992166:3639224-3639442 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 61 bp

>AT240133 NZ_CP094743:2475304-2475364 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References