240132

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2449931..2450448 Replicon chromosome
Accession NZ_CP094743
Organism Staphylococcus aureus strain IVB6252

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA62_RS12130 Protein ID WP_000113260.1
Coordinates 2449931..2450197 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MUA62_RS12135 Protein ID WP_000584499.1
Coordinates 2450197..2450448 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA62_RS12100 (MUA62_12100) 2445083..2445619 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
MUA62_RS12105 (MUA62_12105) 2446141..2446965 - 825 WP_000594633.1 formate/nitrite transporter family protein -
MUA62_RS12110 (MUA62_12110) 2447168..2447350 - 183 WP_000079140.1 hypothetical protein -
MUA62_RS12115 (MUA62_12115) 2447437..2447904 - 468 WP_000153340.1 SRPBCC domain-containing protein -
MUA62_RS12120 (MUA62_12120) 2448090..2449637 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MUA62_RS12125 (MUA62_12125) 2449816..2449896 - 81 WP_225539491.1 hypothetical protein -
MUA62_RS12130 (MUA62_12130) 2449931..2450197 - 267 WP_000113260.1 Txe/YoeB family addiction module toxin Toxin
MUA62_RS12135 (MUA62_12135) 2450197..2450448 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA62_RS12140 (MUA62_12140) 2450613..2450693 - 81 WP_225539489.1 hypothetical protein -
MUA62_RS12145 (MUA62_12145) 2450721..2451320 - 600 WP_000162810.1 DsbA family protein -
MUA62_RS12150 (MUA62_12150) 2451339..2451701 - 363 WP_000819843.1 DUF4467 domain-containing protein -
MUA62_RS12155 (MUA62_12155) 2451956..2453206 + 1251 WP_262541930.1 FemA/FemB family glycyltransferase FmhA -
MUA62_RS12160 (MUA62_12160) 2453303..2454034 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MUA62_RS12165 (MUA62_12165) 2454031..2454750 - 720 WP_000479579.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.99 Da        Isoelectric Point: 10.0373

>T240132 WP_000113260.1 NZ_CP094743:c2450197-2449931 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T240132 NZ_LS992166:2761800-2761907 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT240132 WP_000584499.1 NZ_CP094743:c2450448-2450197 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT240132 NZ_LS992166:c2761750-2761687 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References