Detailed information of TA system TA240125

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1582948..1583527
• Replicon: chromosome
• Accession: NZ_CP094743
• Organism: Staphylococcus aureus strain IVB6252

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: MUA62_RS07605
• Protein ID: WP_001025401.1
• Coordinates: 1583282..1583527 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1582948..1583313 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA62_RS07565 (MUA62_07565)	1579690..1580247	-	558	WP_000645049.1	DUF2815 family protein	-
MUA62_RS07570 (MUA62_07570)	1580274..1581440	-	1167	WP_262612649.1	DUF2800 domain-containing protein	-
MUA62_RS07575 (MUA62_07575)	1581437..1581799	-	363	WP_000985986.1	hypothetical protein	-
MUA62_RS07580 (MUA62_07580)	1581814..1582137	-	324	WP_000175000.1	hypothetical protein	-
MUA62_RS07585 (MUA62_07585)	1582216..1582377	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
MUA62_RS07590 (MUA62_07590)	1582390..1582653	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
MUA62_RS07595 (MUA62_07595)	1582678..1582893	-	216	WP_001097552.1	hypothetical protein	-
MUA62_RS07600 (MUA62_07600)	1582948..1583313	+	366	WP_001128433.1	hypothetical protein	Antitoxin
MUA62_RS07605 (MUA62_07605)	1583282..1583527	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
MUA62_RS07610 (MUA62_07610)	1583543..1583791	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
MUA62_RS07615 (MUA62_07615)	1583955..1584278	+	324	WP_001260486.1	helix-turn-helix transcriptional regulator	-
MUA62_RS07620 (MUA62_07620)	1584291..1584752	+	462	WP_262541840.1	toxin	-
MUA62_RS07625 (MUA62_07625)	1584770..1585204	+	435	WP_031903825.1	hypothetical protein	-
MUA62_RS07630 (MUA62_07630)	1585232..1585627	+	396	WP_001558060.1	hypothetical protein	-
MUA62_RS07635 (MUA62_07635)	1585735..1585926	+	192	WP_252559444.1	hypothetical protein	-
MUA62_RS07640 (MUA62_07640)	1585923..1586501	-	579	WP_252559441.1	hypothetical protein	-
MUA62_RS07645 (MUA62_07645)	1586627..1587832	+	1206	WP_000264747.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541157..1600588	59431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T240125 WP_001025401.1 NZ_CP094743:c1583527-1583282 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T240125 NZ_LS992166:1936581-1936832 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Nucleotide

• Length: 366 bp

>AT240125 NZ_CP094743:1582948-1583313 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTTGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin