240123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 348133..348547 Replicon chromosome
Accession NZ_CP094743
Organism Staphylococcus aureus strain IVB6252

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUA62_RS01565 Protein ID WP_110166336.1
Coordinates 348133..348384 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUA62_RS01570 Protein ID WP_000028424.1
Coordinates 348374..348547 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA62_RS01500 (MUA62_01500) 343297..344082 + 786 WP_262542124.1 ATP-binding protein -
MUA62_RS01505 (MUA62_01505) 344079..344239 + 161 Protein_298 hypothetical protein -
MUA62_RS01510 (MUA62_01510) 344252..344473 + 222 WP_001123695.1 DUF3269 family protein -
MUA62_RS01515 (MUA62_01515) 344484..344888 + 405 WP_000049784.1 DUF1064 domain-containing protein -
MUA62_RS01520 (MUA62_01520) 344893..345078 + 186 WP_001187242.1 DUF3113 family protein -
MUA62_RS01525 (MUA62_01525) 345079..345696 + 618 WP_262529389.1 SA1788 family PVL leukocidin-associated protein -
MUA62_RS01530 (MUA62_01530) 345696..345953 + 258 WP_031864864.1 DUF3310 domain-containing protein -
MUA62_RS01535 (MUA62_01535) 345956..346156 + 201 WP_252549766.1 hypothetical protein -
MUA62_RS01540 (MUA62_01540) 346153..346842 + 690 WP_252549763.1 N-6 DNA methylase -
MUA62_RS01545 (MUA62_01545) 346856..347062 + 207 WP_252549760.1 hypothetical protein -
MUA62_RS01550 (MUA62_01550) 347090..347491 + 402 WP_262542127.1 hypothetical protein -
MUA62_RS01555 (MUA62_01555) 347488..347835 + 348 WP_252570428.1 YopX family protein -
MUA62_RS01560 (MUA62_01560) 347832..348053 + 222 Protein_309 hypothetical protein -
MUA62_RS01565 (MUA62_01565) 348133..348384 + 252 WP_110166336.1 DUF1024 family protein Toxin
MUA62_RS01570 (MUA62_01570) 348374..348547 + 174 WP_000028424.1 hypothetical protein Antitoxin
MUA62_RS01575 (MUA62_01575) 348548..348829 + 282 WP_000454994.1 hypothetical protein -
MUA62_RS01580 (MUA62_01580) 348830..348991 + 162 WP_000889683.1 hypothetical protein -
MUA62_RS01585 (MUA62_01585) 349006..349539 + 534 WP_025920701.1 dUTP diphosphatase -
MUA62_RS01590 (MUA62_01590) 349576..349782 + 207 WP_033859700.1 DUF1381 domain-containing protein -
MUA62_RS01595 (MUA62_01595) 349779..349928 + 150 WP_000595265.1 transcriptional activator RinB -
MUA62_RS01600 (MUA62_01600) 349928..350128 + 201 WP_111761860.1 DUF1514 family protein -
MUA62_RS01605 (MUA62_01605) 350151..350612 + 462 WP_086037675.1 hypothetical protein -
MUA62_RS01610 (MUA62_01610) 350727..351179 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
MUA62_RS01615 (MUA62_01615) 351195..351539 + 345 WP_000817289.1 HNH endonuclease -
MUA62_RS01620 (MUA62_01620) 351668..352138 + 471 WP_262542129.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 332464..373897 41433


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9445.35 Da        Isoelectric Point: 3.9476

>T240123 WP_110166336.1 NZ_CP094743:348133-348384 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGMTNAIQHSVREGIELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T240123 NZ_LS992166:952676-953083 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATCCACGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATGCTCGCCAGGGAGAAATTCGCCTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT240123 WP_000028424.1 NZ_CP094743:348374-348547 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT240123 NZ_LS992166:952429-952695 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCCGATC
TGTTCAACTGGCTGATGAATCATGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References