Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2122893..2123406 Replicon chromosome
Accession NZ_CP094717
Organism Staphylococcus sp. IVB6246

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MUA26_RS10655 Protein ID WP_262614171.1
Coordinates 2122893..2123159 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MUA26_RS10660 Protein ID WP_262614172.1
Coordinates 2123152..2123406 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA26_RS10620 (MUA26_10590) 2118189..2118656 - 468 WP_262614166.1 DUF523 domain-containing protein -
MUA26_RS10625 (MUA26_10595) 2118758..2118940 - 183 WP_262604120.1 hypothetical protein -
MUA26_RS10630 (MUA26_10600) 2119226..2119582 + 357 WP_262614167.1 cyclophilin-like fold protein -
MUA26_RS10635 (MUA26_10605) 2119702..2120691 - 990 WP_262614168.1 adenosine deaminase -
MUA26_RS10640 (MUA26_10610) 2120888..2121736 - 849 WP_262614169.1 LPXTG cell wall anchor domain-containing protein -
MUA26_RS10645 (MUA26_10615) 2121694..2122134 - 441 WP_262614716.1 trypsin-like serine protease -
MUA26_RS10650 (MUA26_10620) 2122224..2122613 - 390 WP_262614170.1 hypothetical protein -
MUA26_RS10655 (MUA26_10625) 2122893..2123159 - 267 WP_262614171.1 Txe/YoeB family addiction module toxin Toxin
MUA26_RS10660 (MUA26_10630) 2123152..2123406 - 255 WP_262614172.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA26_RS10665 (MUA26_10635) 2124265..2125284 - 1020 WP_262614173.1 DUF418 domain-containing protein -
MUA26_RS10670 (MUA26_10640) 2125964..2126434 - 471 WP_262614174.1 terminase small subunit -
MUA26_RS10675 (MUA26_10645) 2126431..2126775 - 345 WP_262614175.1 pathogenicity island protein -
MUA26_RS10680 (MUA26_10650) 2126778..2127288 - 511 Protein_2054 spore coat protein -
MUA26_RS10685 (MUA26_10655) 2127341..2127991 - 651 WP_262614717.1 hypothetical protein -
MUA26_RS10690 (MUA26_10660) 2128026..2128370 - 345 WP_262614176.1 pathogenicity island protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10485.20 Da        Isoelectric Point: 9.8515

>T240056 WP_262614171.1 NZ_CP094717:c2123159-2122893 [Staphylococcus sp. IVB6246]
MSKLNITFTPTAFEDYEYWLKQDKKLLRKINSLIKSIQRDGILEGEGKPEPLKGNLRGYCSRRINHEHRLVYAIKDNQMI
IIACRYHY

Download         Length: 267 bp

>T240056 NZ_LS483484:c2153314-2153063 [Staphylococcus aureus]
ATGAATAATCGCGAACAAATTGAACAATCAGTTATAAGTGCTAGTGCGTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGATTGAGGACGTTTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAATATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGCATTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9529.56 Da        Isoelectric Point: 4.3707

>AT240056 WP_262614172.1 NZ_CP094717:c2123406-2123152 [Staphylococcus sp. IVB6246]
MTVLTYSNARKNFRRLIDKVNEDSDTVTITTNNKNAVLMSEADYNSIMETLYLQQSPVNAKHLSQSIAEAENKNVVDVDI
DSYE

Download         Length: 255 bp

>AT240056 NZ_LS483484:c2153073-2152891 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGAGCAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References