Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2491210..2491733 | Replicon | chromosome |
| Accession | NZ_CP094714 | ||
| Organism | Staphylococcus schleiferi strain IVB6176 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | S2XCX2 |
| Locus tag | MUA72_RS11915 | Protein ID | WP_016425657.1 |
| Coordinates | 2491467..2491733 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S2XXM7 |
| Locus tag | MUA72_RS11910 | Protein ID | WP_016425656.1 |
| Coordinates | 2491210..2491467 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA72_RS11860 (MUA72_11820) | 2486246..2486431 | + | 186 | WP_016425649.1 | hypothetical protein | - |
| MUA72_RS11865 (MUA72_11825) | 2486441..2486893 | + | 453 | WP_016425650.1 | DUF523 domain-containing protein | - |
| MUA72_RS11870 (MUA72_11830) | 2487108..2487332 | - | 225 | WP_167512896.1 | hypothetical protein | - |
| MUA72_RS11875 (MUA72_11835) | 2487347..2487508 | + | 162 | WP_228446226.1 | hypothetical protein | - |
| MUA72_RS11880 (MUA72_11840) | 2487628..2487840 | + | 213 | WP_231371820.1 | hypothetical protein | - |
| MUA72_RS11885 (MUA72_11845) | 2487945..2488280 | + | 336 | WP_257211757.1 | Msa family membrane protein | - |
| MUA72_RS11890 (MUA72_11850) | 2488331..2489143 | + | 813 | WP_231371814.1 | ABC transporter ATP-binding protein | - |
| MUA72_RS11895 (MUA72_11855) | 2489136..2489891 | + | 756 | WP_016425653.1 | hypothetical protein | - |
| MUA72_RS11900 (MUA72_11860) | 2489901..2490077 | + | 177 | WP_016425654.1 | hypothetical protein | - |
| MUA72_RS11905 (MUA72_11865) | 2490144..2490977 | + | 834 | WP_016425655.1 | CPBP family intramembrane metalloprotease | - |
| MUA72_RS11910 (MUA72_11870) | 2491210..2491467 | + | 258 | WP_016425656.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUA72_RS11915 (MUA72_11875) | 2491467..2491733 | + | 267 | WP_016425657.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUA72_RS11920 (MUA72_11880) | 2492172..2492885 | - | 714 | WP_228446227.1 | ISL3 family transposase | - |
| MUA72_RS11925 (MUA72_11885) | 2492882..2493490 | - | 609 | WP_236249159.1 | transposase family protein | - |
| MUA72_RS11930 (MUA72_11890) | 2493778..2494314 | + | 537 | WP_016425660.1 | 4'-phosphopantetheinyl transferase superfamily protein | - |
| MUA72_RS11935 (MUA72_11895) | 2494320..2494820 | + | 501 | WP_016425661.1 | MepB family protein | - |
| MUA72_RS11940 (MUA72_11900) | 2494965..2495327 | + | 363 | WP_016425662.1 | transposase | - |
| MUA72_RS11945 (MUA72_11905) | 2495531..2496199 | - | 669 | WP_194368734.1 | saccharopine dehydrogenase NADP-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10646.09 Da Isoelectric Point: 9.7537
>T240043 WP_016425657.1 NZ_CP094714:2491467-2491733 [Staphylococcus schleiferi]
MSYYSVLIKNSAKSDLKKINKSHLKEQFLNVVETLKIDPYEPSQSFEKLQPKHLGRYSRRINHQHRVVYTVDDEKREVYI
FSTWSHYE
MSYYSVLIKNSAKSDLKKINKSHLKEQFLNVVETLKIDPYEPSQSFEKLQPKHLGRYSRRINHQHRVVYTVDDEKREVYI
FSTWSHYE
Download Length: 267 bp
>T240043 NZ_LS483480:580347-580484 [Haemophilus influenzae]
ATGAATGAAGATATGGCGAATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGA
TATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA
ATGAATGAAGATATGGCGAATCTCTTTCAGGCAATGAATGCACTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGA
TATTCGCGCTTTTCGTATTGAGCAATGGTCTGATTTTACTGATTTTATACGAAATTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9781.91 Da Isoelectric Point: 5.1133
>AT240043 WP_016425656.1 NZ_CP094714:2491210-2491467 [Staphylococcus schleiferi]
MNIKTPTNARKEFYELLKHVNVNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVRKREKDDSGYTNIEDL
DWGNL
MNIKTPTNARKEFYELLKHVNVNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVRKREKDDSGYTNIEDL
DWGNL
Download Length: 258 bp
>AT240043 NZ_LS483480:580007-580198 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA
ATGGAACTAAGACAACAAATTCCAACAGGCTGTATTAAGCAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGTGATGTGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGACATTTATCGATTAT
CTCACCTGCTTGAAGATCCCGAAGCTGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|