240034

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2499163..2499686 Replicon chromosome
Accession NZ_CP094711
Organism Staphylococcus schleiferi strain IVB6184

Toxin (Protein)


Gene name yoeB Uniprot ID S2XCX2
Locus tag MUA46_RS11955 Protein ID WP_016425657.1
Coordinates 2499420..2499686 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S2XXM7
Locus tag MUA46_RS11950 Protein ID WP_016425656.1
Coordinates 2499163..2499420 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA46_RS11905 (MUA46_11865) 2494200..2494385 + 186 WP_016425649.1 hypothetical protein -
MUA46_RS11910 (MUA46_11870) 2494395..2494847 + 453 WP_016425650.1 DUF523 domain-containing protein -
MUA46_RS11915 (MUA46_11875) 2495062..2495286 - 225 WP_167512896.1 hypothetical protein -
MUA46_RS11920 (MUA46_11880) 2495301..2495462 + 162 WP_228446226.1 hypothetical protein -
MUA46_RS11925 (MUA46_11885) 2495582..2495794 + 213 WP_231371820.1 hypothetical protein -
MUA46_RS11930 (MUA46_11890) 2495899..2496234 + 336 WP_257211757.1 Msa family membrane protein -
MUA46_RS11935 (MUA46_11895) 2496285..2497097 + 813 WP_231371814.1 ABC transporter ATP-binding protein -
MUA46_RS11940 (MUA46_11900) 2497854..2498030 + 177 WP_016425654.1 hypothetical protein -
MUA46_RS11945 (MUA46_11905) 2498097..2498930 + 834 WP_016425655.1 CPBP family intramembrane metalloprotease -
MUA46_RS11950 (MUA46_11910) 2499163..2499420 + 258 WP_016425656.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MUA46_RS11955 (MUA46_11915) 2499420..2499686 + 267 WP_016425657.1 Txe/YoeB family addiction module toxin Toxin
MUA46_RS11960 (MUA46_11920) 2500125..2500838 - 714 WP_228446227.1 ISL3 family transposase -
MUA46_RS11965 (MUA46_11925) 2500835..2501443 - 609 WP_236249159.1 transposase family protein -
MUA46_RS11970 (MUA46_11930) 2501731..2502267 + 537 WP_016425660.1 4'-phosphopantetheinyl transferase superfamily protein -
MUA46_RS11975 (MUA46_11935) 2502273..2502773 + 501 WP_016425661.1 MepB family protein -
MUA46_RS11980 (MUA46_11940) 2502918..2503280 + 363 WP_016425662.1 transposase -
MUA46_RS11985 (MUA46_11945) 2503484..2504152 - 669 WP_194368734.1 saccharopine dehydrogenase NADP-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(24-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.09 Da        Isoelectric Point: 9.7537

>T240034 WP_016425657.1 NZ_CP094711:2499420-2499686 [Staphylococcus schleiferi]
MSYYSVLIKNSAKSDLKKINKSHLKEQFLNVVETLKIDPYEPSQSFEKLQPKHLGRYSRRINHQHRVVYTVDDEKREVYI
FSTWSHYE

Download         Length: 267 bp

>T240034 NZ_LS483471:1049695-1050462 [Streptococcus cristatus]
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGAACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACCTCATCTCATCCTAAGGCTATTTTGCTCGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCTTTTCATCCGAACTACCTTGGCCTACAGGAA
AAGTATGGCAAAGATAGTGTAGATTATACCAAAGTGTTTGCGGGACAAATGGTTGAATATCTTGTAGATGAGTTGAGTAA
AAAAGGTTATCATTTGTTAATCGAGGGTACCTTGAGAACAACAGAAGTTCCCCGAAAAACGGCCCAATTATTGGCAACTA
GAGGATATCAAGTCTCACTTGCACTGATTGCGACCAAGCCAGAATTGTCTTATCTCAGTACCTTGATTCGTTATGAGGAG
CTCTACGCCATAGATCCTAGTCAAGCAAGGGCGACTCCCAAAGAGCACCATGATGGAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGTTAGAAAATGACAAAATTTTTAATCAAATTCAAATTTATCAAAGAGATCAATCGTGTGTTTATGATTCGC
AAGTAGACGGAACCTCAGCAGCAGAAGTTCTACAAGAATGCCTATTTGGAAAATGGAGTAAGGTGGAGGAAGAAATGTTG
AATTGGGGACAGGAACGGTTGAGAGAGTTGGGGGAAATTGATAAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9781.91 Da        Isoelectric Point: 5.1133

>AT240034 WP_016425656.1 NZ_CP094711:2499163-2499420 [Staphylococcus schleiferi]
MNIKTPTNARKEFYELLKHVNVNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVRKREKDDSGYTNIEDL
DWGNL

Download         Length: 258 bp

>AT240034 NZ_LS483471:1049219-1049695 [Streptococcus cristatus]
ATGATTGGAGAAAATATAAAAACGTTACGCAAGGCACATAACCTAACTCAGCCTGAGTTCGCAAAGATTGTTGGTATCTC
TCGAAATAGCCTAAGTCGTTATGAAAATGGAACAAGTTCAGTTTCGACAGAATTAATAGATCGTATCTGCCAGAAATTTA
ATGTTTCCTATATCGATATCGTAGGAGAGGAAAAGATGCTCACACCAGTAGAAGATTACCAGTTGACCCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTTCAAGATGAGCAAGGAATTGCATTTGATGATAC
TTCTAATCCTTGGGTTCTAATGAGCGATGATTTGTCTGATTTAATTAACACGAGGATTTATCTTGTTGCAACTTTTGAGG
ATATAGAGCGATTTAATGGCTATTTGGATGGCATTGAACGTATGCTAGAACAAGCTAGTCATCTGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S2XCX2

Antitoxin

Source ID Structure
AlphaFold DB S2XXM7

References