Detailed information of TA system TA240011

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2282505..2283085
• Replicon: chromosome
• Accession: NZ_CP094698
• Organism: Staphylococcus simulans strain IVB6241

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: -
• Locus tag: MUA31_RS10940
• Protein ID: WP_070684231.1
• Coordinates: 2282840..2283085 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2282505..2282869 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA31_RS10900 (MUA31_10900)	2278689..2280641	-	1953	WP_199194619.1	AAA family ATPase	-
MUA31_RS10905 (MUA31_10905)	2280644..2280910	-	267	WP_262546608.1	DUF1108 family protein	-
MUA31_RS10910 (MUA31_10910)	2281007..2281222	-	216	WP_106421056.1	hypothetical protein	-
MUA31_RS10915 (MUA31_10915)	2281238..2281456	-	219	WP_105988757.1	hypothetical protein	-
MUA31_RS10920 (MUA31_10920)	2281511..2281738	+	228	WP_023015315.1	hypothetical protein	-
MUA31_RS10925 (MUA31_10925)	2281760..2281897	-	138	WP_158257375.1	hypothetical protein	-
MUA31_RS10930 (MUA31_10930)	2282161..2282424	-	264	WP_105988756.1	hypothetical protein	-
-	2282505..2282869	+	365	-	-	Antitoxin
MUA31_RS10940 (MUA31_10940)	2282840..2283085	-	246	WP_070684231.1	DUF2829 domain-containing protein	Toxin
MUA31_RS10945 (MUA31_10945)	2283135..2283362	-	228	WP_105988755.1	hypothetical protein	-
MUA31_RS10950 (MUA31_10950)	2283363..2284130	-	768	Protein_2129	phage antirepressor KilAC domain-containing protein	-
MUA31_RS10955 (MUA31_10955)	2284127..2284381	-	255	WP_262546611.1	helix-turn-helix transcriptional regulator	-
MUA31_RS10960 (MUA31_10960)	2284578..2284910	+	333	WP_105988752.1	helix-turn-helix transcriptional regulator	-
MUA31_RS10965 (MUA31_10965)	2284923..2285396	+	474	WP_107540066.1	ImmA/IrrE family metallo-endopeptidase	-
MUA31_RS10970 (MUA31_10970)	2285401..2285958	+	558	WP_234016559.1	Ltp family lipoprotein	-
MUA31_RS10975 (MUA31_10975)	2286136..2286288	+	153	WP_158257374.1	hypothetical protein	-
MUA31_RS10980 (MUA31_10980)	2286372..2286560	+	189	WP_105988749.1	hypothetical protein	-
MUA31_RS10985 (MUA31_10985)	2286625..2286858	+	234	WP_105988748.1	hypothetical protein	-
MUA31_RS10990 (MUA31_10990)	2287089..2287325	+	237	WP_057510972.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2244375..2310729	66354

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (3-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9419.78 Da
• Isoelectric Point: 6.2121

>T240011 WP_070684231.1 NZ_CP094698:c2283085-2282840 [Staphylococcus simulans]
MSIQEATKLATKELLTMTRKEWKKSHQAQVLPTNDSFLNCIVSSNDGKHLIRHWQPSADDLMADDWEVINPIRDLELLKQ
F

Nucleotide

• Length: 246 bp

>T240011 NZ_LS483450:c1676027-1675773 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAATCAGGATAAGAAAACGTTAAAAAGAAT
CAATAAACTAATCAAGGATATTCAACGTGATCCCTTTACAGGAATAGGTAAACCAGAACCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin

Nucleotide

• Length: 365 bp

>AT240011 NZ_CP094698:2282505-2282869 [Staphylococcus simulans]
ATGACTTTGATAACCGATGAATTCGAAGTACTTACTAAAGATCAACAGTATATTTTGTCAGTACTTTATAAAAATTATTT
AGAATGTGTTAAGTCTGGAGTTGTTAAACTAACTTGTAATAATTTTGAAAGTGCGGAAGATATATACTCTAAACATTTTC
AAAAACTACATTTTGAGGATGTAGAAAATGATTTGAAAAAACTTAAAAAGCATGGATTCCTGAATGGTATTTTTGCAGAT
AACACCATTTATCATGTGACTATTTCAGATAAAAACTATTGTTTATTTCGAAAATGAGTTTAAAAATAATTTAAAAAGTA
TAATTGATAGCATTTCTAAAATTGCTTCAATAATTCCAAGTCTCT

Structures

Antitoxin