Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
| Location | 4110262..4110857 | Replicon | chromosome |
| Accession | NZ_CP094677 | ||
| Organism | Pseudomonas aeruginosa strain Pa150 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | V6ALY3 |
| Locus tag | MTX71_RS19255 | Protein ID | WP_003113526.1 |
| Coordinates | 4110262..4110540 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MTX71_RS19260 | Protein ID | WP_003099268.1 |
| Coordinates | 4110552..4110857 (+) | Length | 102 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MTX71_RS19235 (MTX71_19200) | 4105688..4106926 | + | 1239 | WP_003113524.1 | dipeptidase | - |
| MTX71_RS19240 (MTX71_19205) | 4106988..4107635 | + | 648 | WP_003095021.1 | carbonate dehydratase | - |
| MTX71_RS19245 (MTX71_19210) | 4107705..4109933 | - | 2229 | WP_003099265.1 | TonB-dependent receptor | - |
| MTX71_RS19250 (MTX71_19215) | 4110081..4110209 | + | 129 | Protein_3794 | integrase | - |
| MTX71_RS19255 (MTX71_19220) | 4110262..4110540 | + | 279 | WP_003113526.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| MTX71_RS19260 (MTX71_19225) | 4110552..4110857 | + | 306 | WP_003099268.1 | HigA family addiction module antitoxin | Antitoxin |
| MTX71_RS19270 (MTX71_19235) | 4111252..4112352 | - | 1101 | WP_003099270.1 | redox-regulated ATPase YchF | - |
| MTX71_RS19275 (MTX71_19240) | 4112393..4112977 | - | 585 | WP_003099278.1 | aminoacyl-tRNA hydrolase | - |
| MTX71_RS19280 (MTX71_19245) | 4113019..4113633 | - | 615 | WP_003099279.1 | 50S ribosomal protein L25/general stress protein Ctc | - |
| MTX71_RS19285 (MTX71_19250) | 4113750..4114691 | - | 942 | WP_003099281.1 | ribose-phosphate pyrophosphokinase | - |
| MTX71_RS19295 (MTX71_19260) | 4114858..4115706 | - | 849 | WP_003146058.1 | 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10646.19 Da Isoelectric Point: 7.8937
>T239999 WP_003113526.1 NZ_CP094677:4110262-4110540 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T239999 NZ_LS483444:c1792601-1791816 [Streptococcus australis]
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGGACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACTTCGTCTCGGCCCAAGGCTATCTTGCTAGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCATTTCATCCGAACTACCTTGGCCTACAGGAA
AAGTATGGCAAAGATAGTGTGGATTATACCAAAGTATTTGCGGGACGAATGGTTGAATATCTCGTAGATGAATTGAGTAA
ACTAGGCTATCATTTGTTAATCGAGGGTACCTTGAGAACAACAGAAGTTCCTCGAAAGACGGCACAATTATTGGTAATTA
GAGGTTACCAAGTCTCACTTGCACTGATTGCGACCAAGCCTGAATTGTCCTATCTCAGCACCTTGATACGTTATGAAGAG
CTCTATGCTATAGATCCTAATCAAGCTAGAGCAACTCCCAAAGAGCACCATGATGAAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGTTAGAAAATGATAATATTTTTAATCAAATTCAAATTTTTCAAAGAGATCAATCGTGCGTTTATGATTCGC
AAGTAGATGAAACCTCAGCAGCAGAAGTTCTACACGAATGCCTCTTCGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTT
AAGATGGGGCAGGAACGGTTGAGAGAATTAATGGAAATGAAAAAAGGTATAATTGATGGAAATTAA
ATGAAACTAGAAGAATTTAGTCAAGATGATTTTGGACGAGCATCCAGACGACTCGTTCGTTCTTTAACTCGTGGTAAAAC
AACTTCGTCTCGGCCCAAGGCTATCTTGCTAGGTGGACAGAGTGGTGCTGGGAAAACAACGATTCATCGTATTAAACAAA
GGGAATTTCAAGGTAATATCATTATCATTGATGGAGATAGTTATCGCTCATTTCATCCGAACTACCTTGGCCTACAGGAA
AAGTATGGCAAAGATAGTGTGGATTATACCAAAGTATTTGCGGGACGAATGGTTGAATATCTCGTAGATGAATTGAGTAA
ACTAGGCTATCATTTGTTAATCGAGGGTACCTTGAGAACAACAGAAGTTCCTCGAAAGACGGCACAATTATTGGTAATTA
GAGGTTACCAAGTCTCACTTGCACTGATTGCGACCAAGCCTGAATTGTCCTATCTCAGCACCTTGATACGTTATGAAGAG
CTCTATGCTATAGATCCTAATCAAGCTAGAGCAACTCCCAAAGAGCACCATGATGAAATTGTAGAACATTTAGTTGATAA
CTTACGAGAGTTAGAAAATGATAATATTTTTAATCAAATTCAAATTTTTCAAAGAGATCAATCGTGCGTTTATGATTCGC
AAGTAGATGAAACCTCAGCAGCAGAAGTTCTACACGAATGCCTCTTCGGAAAATGGAGTAAGGTGGAGGAAGAGATGTTT
AAGATGGGGCAGGAACGGTTGAGAGAATTAATGGAAATGAAAAAAGGTATAATTGATGGAAATTAA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11213.79 Da Isoelectric Point: 5.0747
>AT239999 WP_003099268.1 NZ_CP094677:4110552-4110857 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
Download Length: 306 bp
>AT239999 NZ_LS483444:c1793077-1792601 [Streptococcus australis]
ATGATCGGAGAAAATATTAAAGCGTTACGTAAAACACATGACCTAACCCAGCCTGAGTTCGCAAAGATTGTTGGCATCTC
TCGAAATAGCCTGAGTCGTTATGAAAACGGGACAAGTTCAGTTTCGACAGAATTAATAGATCGTATTTGTCAGAAATTTA
ATGTTTCTTATATCGATATTGTAGGAGAGGAAAAGATGCTCACGCCAGTAGAAGATTATCAGTTAACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTACAAGATGAACTAGAAATTGCATTTGATGATGC
TAATAATCCGTGGGTTCTAATAAGCGATGATCTTTCTGATTTGATTAACACGAAGATTTATCTTGTTGCAACTTTTGAGG
ATGTGGAGCGATATAATGGCTATTTGGATGGCATTGAACGGATGCTAGAACAAGCCAGTCATCTGGTGGTGGCTTAA
ATGATCGGAGAAAATATTAAAGCGTTACGTAAAACACATGACCTAACCCAGCCTGAGTTCGCAAAGATTGTTGGCATCTC
TCGAAATAGCCTGAGTCGTTATGAAAACGGGACAAGTTCAGTTTCGACAGAATTAATAGATCGTATTTGTCAGAAATTTA
ATGTTTCTTATATCGATATTGTAGGAGAGGAAAAGATGCTCACGCCAGTAGAAGATTATCAGTTAACTCTGAAAATTGAA
GTGATTAAAGAACGAGGGGCGAATATCTTAGCGCAACTTTATCGTTTACAAGATGAACTAGAAATTGCATTTGATGATGC
TAATAATCCGTGGGTTCTAATAAGCGATGATCTTTCTGATTTGATTAACACGAAGATTTATCTTGTTGCAACTTTTGAGG
ATGTGGAGCGATATAATGGCTATTTGGATGGCATTGAACGGATGCTAGAACAAGCCAGTCATCTGGTGGTGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|