Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 6467622..6468136 Replicon chromosome
Accession NZ_CP094676
Organism Streptomyces sp. CB09030

Toxin (Protein)


Gene name yoeB Uniprot ID A0A6G9ES44
Locus tag L6J92_RS27610 Protein ID WP_031030578.1
Coordinates 6467882..6468136 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A6G9ESD1
Locus tag L6J92_RS27605 Protein ID WP_031030581.1
Coordinates 6467622..6467885 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L6J92_RS27595 (L6J92_27595) 6463358..6464218 + 861 WP_195890169.1 phosphatase PAP2 family protein -
L6J92_RS27600 (L6J92_27600) 6464459..6467470 - 3012 WP_243782290.1 bifunctional [glutamine synthetase] adenylyltransferase/[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase -
L6J92_RS27605 (L6J92_27605) 6467622..6467885 + 264 WP_031030581.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L6J92_RS27610 (L6J92_27610) 6467882..6468136 + 255 WP_031030578.1 Txe/YoeB family addiction module toxin Toxin
L6J92_RS27615 (L6J92_27615) 6468221..6468667 + 447 WP_194277962.1 VOC family protein -
L6J92_RS27620 (L6J92_27620) 6468695..6470467 - 1773 WP_243782291.1 NAD+ synthase -
L6J92_RS27625 (L6J92_27625) 6470616..6471245 - 630 WP_194277960.1 DUF305 domain-containing protein -
L6J92_RS27630 (L6J92_27630) 6471242..6471910 - 669 WP_194277959.1 DUF3105 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9911.23 Da        Isoelectric Point: 9.7377

>T239996 WP_031030578.1 NZ_CP094676:6467882-6468136 [Streptomyces sp. CB09030]
VRVTFTSHGWEDYVHWAESDRKVTKRINRLIDDITRDPFKGIGKPEPLKGDLSGYWSRRIDDTHRLVYKPADGVLVIVQA
RYHY

Download         Length: 255 bp

>T239996 NZ_LS483442:1563876-1564211 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGATCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9784.92 Da        Isoelectric Point: 4.8784

>AT239996 WP_031030581.1 NZ_CP094676:6467622-6467885 [Streptomyces sp. CB09030]
MPITASEARQNLFPLIEQVNEDHAPVHITSRKGNAVLMSEEDFTAWTETVHLLRSPKNARRLLDSIAEAEAGEARHRELI
DPDAERA

Download         Length: 264 bp

>AT239996 NZ_LS483442:1563599-1563886 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAGGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G9ES44

Antitoxin

Source ID Structure
AlphaFold DB A0A6G9ESD1

References