Detailed information of TA system TA239989

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 1951221..1951405
• Replicon: chromosome
• Accession: NZ_CP094663
• Organism: Staphylococcus aureus strain 494

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MT995_RS09890
• Protein ID: WP_000482652.1
• Coordinates: 1951298..1951405 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	1951221..1951281 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT995_RS09875	1946676..1946807	-	132	WP_223197975.1	hypothetical protein	-
MT995_RS09880	1947074..1948807	-	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MT995_RS09885	1948832..1950595	-	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
-	1951221..1951281	+	61	-	-	Antitoxin
MT995_RS09890	1951298..1951405	-	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
MT995_RS09895	1951539..1951925	-	387	WP_000779360.1	flippase GtxA	-
MT995_RS09900	1952193..1953335	+	1143	WP_001176863.1	glycerate kinase	-
MT995_RS09905	1953395..1954054	+	660	WP_000831298.1	membrane protein	-
MT995_RS09910	1954236..1955447	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
MT995_RS09915	1955570..1956043	-	474	WP_000456486.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T239989 WP_000482652.1 NZ_CP094663:c1951405-1951298 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T239989 NZ_LS483433:5752056-5752934 [Pseudomonas mucidolens]
ATGTTGCCAGGACTCTCTCAAGCCCCGCCGACGGCTGACCTGCAAGCCCAGTTGGAGCGCGACTTTCCCCAGCGCCTGGT
GCTCGCAGCCGGTGGCCGGCAGGCGCTGCGCGAATGTGGCGCGGGGCCGACAGTGGTCATGCTGCACGGCATCGGCTCCG
GGGCGGCGTCCTGGCTGCAAGTGGCCCAACACTTGGCGCCCCGCGCTCGGGTCATCGCCTGGGACGCGCCGGGCTACGGT
GATTCCAGCCCCCTGGAGTCAGACGCGCCGAAGGCCGAGCAGTACGCGACGCGGCTGGCACAGATGCTGGATGCCCTGAG
TGTCGAGCAGTGCGTGCTAGTGGGCCACTCCCTCGGCGCGTTGACCGCCCTGGCGCTGGCGCGTAGCTCACAGGCCAATC
GAGTGAGCCGCCTGATATTGATCAGCCCGGCTCGCGGCTATGGCGCACCGCAACACGCCGCGCAGCGCCAGCAGGTACGC
CAGCAACGCCTGGACAATCTGCAACGCCTGGGTATCGCCGGCCTGGCCAAAGAACGCAGCGCCCACATGCTGTCGCCTTG
TGCCACGCCCCAGGCCCTGGCCTGGGTGCGTTGGAACATGGAGCGCCTGAACCCGGTCGGCTATCGCCAGGCAATCGAGT
TGTTGTGCGGTGATGACCTGTTGCGCCACGGCCAGCCCGACATGCCCTGCGAAGTGCATTGCGGCGAGGCCGACAGCATC
ACCACCGCCCAAACCTGCCTGAGCGTAGCCAAGGCGCTGGGCGCCGGCTTCAACCTGATTGCCGACGCCGGTCATGCCAG
CCCCATCGAACAACCGCAGGTGGTAGCCGGTCGCCTGGCCTTTGCCATCCAACAATCCCTGACAGGTACACGCCTATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT239989 NZ_CP094663:1951221-1951281 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin