Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 1925726..1926243 | Replicon | chromosome |
| Accession | NZ_CP094663 | ||
| Organism | Staphylococcus aureus strain 494 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | MT995_RS09755 | Protein ID | WP_000113265.1 |
| Coordinates | 1925726..1925992 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | MT995_RS09760 | Protein ID | WP_000584499.1 |
| Coordinates | 1925992..1926243 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MT995_RS09725 (1921154) | 1921154..1921690 | - | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
| MT995_RS09730 (1921924) | 1921924..1922748 | - | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| MT995_RS09735 (1922965) | 1922965..1923147 | - | 183 | WP_000230292.1 | hypothetical protein | - |
| MT995_RS09740 (1923231) | 1923231..1923698 | - | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| MT995_RS09745 (1923884) | 1923884..1925431 | - | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| MT995_RS09750 (1925620) | 1925620..1925691 | - | 72 | Protein_1885 | hypothetical protein | - |
| MT995_RS09755 (1925726) | 1925726..1925992 | - | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| MT995_RS09760 (1925992) | 1925992..1926243 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MT995_RS09765 (1926408) | 1926408..1926488 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| MT995_RS09770 (1926516) | 1926516..1927115 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| MT995_RS09775 (1927134) | 1927134..1927496 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| MT995_RS09780 (1927751) | 1927751..1929001 | + | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| MT995_RS09785 (1929098) | 1929098..1929829 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| MT995_RS09790 (1929826) | 1929826..1930545 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T239988 WP_000113265.1 NZ_CP094663:c1925992-1925726 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T239988 NZ_LS483432:1600541-1600876 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT239988 WP_000584499.1 NZ_CP094663:c1926243-1925992 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT239988 NZ_LS483432:1600264-1600551 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|