Detailed information of TA system TA239988

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1925726..1926243
• Replicon: chromosome
• Accession: NZ_CP094663
• Organism: Staphylococcus aureus strain 494

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A3A3ATA4
• Locus tag: MT995_RS09755
• Protein ID: WP_000113265.1
• Coordinates: 1925726..1925992 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: MT995_RS09760
• Protein ID: WP_000584499.1
• Coordinates: 1925992..1926243 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT995_RS09725 (1921154)	1921154..1921690	-	537	WP_000169317.1	GNAT family N-acetyltransferase	-
MT995_RS09730 (1921924)	1921924..1922748	-	825	WP_000572038.1	formate/nitrite transporter family protein	-
MT995_RS09735 (1922965)	1922965..1923147	-	183	WP_000230292.1	hypothetical protein	-
MT995_RS09740 (1923231)	1923231..1923698	-	468	WP_000153347.1	SRPBCC domain-containing protein	-
MT995_RS09745 (1923884)	1923884..1925431	-	1548	WP_000727772.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
MT995_RS09750 (1925620)	1925620..1925691	-	72	Protein_1885	hypothetical protein	-
MT995_RS09755 (1925726)	1925726..1925992	-	267	WP_000113265.1	Txe/YoeB family addiction module toxin	Toxin
MT995_RS09760 (1925992)	1925992..1926243	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MT995_RS09765 (1926408)	1926408..1926488	-	81	WP_223197974.1	hypothetical protein	-
MT995_RS09770 (1926516)	1926516..1927115	-	600	WP_000162810.1	DsbA family protein	-
MT995_RS09775 (1927134)	1927134..1927496	-	363	WP_000819843.1	DUF4467 domain-containing protein	-
MT995_RS09780 (1927751)	1927751..1929001	+	1251	WP_001012225.1	FemA/FemB family glycyltransferase FmhA	-
MT995_RS09785 (1929098)	1929098..1929829	-	732	WP_000615461.1	amino acid ABC transporter ATP-binding protein	-
MT995_RS09790 (1929826)	1929826..1930545	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10436.96 Da
• Isoelectric Point: 10.0573

>T239988 WP_000113265.1 NZ_CP094663:c1925992-1925726 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T239988 NZ_LS483432:1600541-1600876 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT239988 WP_000584499.1 NZ_CP094663:c1926243-1925992 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT239988 NZ_LS483432:1600264-1600551 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• PDB: 7BWF

Antitoxin

• AlphaFold DB: T1YB60