Detailed information of TA system TA239986

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 1666157..1666373
• Replicon: chromosome
• Accession: NZ_CP094663
• Organism: Staphylococcus aureus strain 494

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MT995_RS08410
• Protein ID: WP_001802298.1
• Coordinates: 1666269..1666373 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1666157..1666212 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT995_RS08385	1662363..1663028	-	666	WP_001024095.1	SDR family oxidoreductase	-
MT995_RS08390	1663180..1663500	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MT995_RS08395	1663502..1664479	+	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
MT995_RS08400	1664745..1665836	+	1092	WP_000495669.1	hypothetical protein	-
-	1666157..1666212	+	56	-	-	Antitoxin
MT995_RS08410	1666269..1666373	-	105	WP_001802298.1	hypothetical protein	Toxin
MT995_RS08415	1667053..1667211	+	159	WP_001792784.1	hypothetical protein	-
MT995_RS08420	1667869..1668726	-	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
MT995_RS08425	1668794..1669576	-	783	WP_000908182.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T239986 WP_001802298.1 NZ_CP094663:c1666373-1666269 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T239986 NZ_LS483429:c1667625-1667320 [Haemophilus aegyptius]
ATGTTTAATTTAAAGCGTGAGCATTTTAGAGATGATTATCTTTATAGGTTTTATCAATATGGTGATACTCATAGTAAGAT
TCCTTCTAATTTGTATAAAGTATTGGCAAGAAAATTAGATATGATAAGTGCCTCAGAAAATATCAACGATTTACGTTCTC
CACCAGCTAACCATTTGGAGTTGCTTGAGCCAAAAGAAAATAAAATTTATTCTATTCGAGTGAATAAACAATATCGTTTA
ATTTTTAAATATGAAAATAACGAAGTAAATAATTTATATTTAGATCCACATTCTTATAATTTGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT239986 NZ_CP094663:1666157-1666212 [Staphylococcus aureus]
AAAAAGGGCAACACTCGGAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin