Detailed information of TA system TA239982

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 1493436..1493735
• Replicon: chromosome
• Accession: NZ_CP094663
• Organism: Staphylococcus aureus strain 494

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MT995_RS07425
• Protein ID: WP_011447039.1
• Coordinates: 1493559..1493735 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	1493436..1493491 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT995_RS07385	1488994..1489173	+	180	WP_000669789.1	hypothetical protein	-
MT995_RS07390	1489484..1489744	+	261	WP_001791826.1	hypothetical protein	-
MT995_RS07395	1489797..1490147	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
MT995_RS07400	1490658..1490993	-	336	Protein_1428	SH3 domain-containing protein	-
MT995_RS07405	1491644..1492135	-	492	WP_000920038.1	staphylokinase	-
MT995_RS07410	1492326..1493081	-	756	WP_000861038.1	CHAP domain-containing protein	-
MT995_RS07415	1493093..1493347	-	255	WP_000611512.1	phage holin	-
MT995_RS07420	1493399..1493506	+	108	WP_001791821.1	hypothetical protein	-
-	1493428..1493567	+	140	NuclAT_0	-	-
-	1493428..1493567	+	140	NuclAT_0	-	-
-	1493428..1493567	+	140	NuclAT_0	-	-
-	1493428..1493567	+	140	NuclAT_0	-	-
-	1493436..1493491	+	56	-	-	Antitoxin
MT995_RS07425	1493559..1493735	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
MT995_RS07430	1493885..1494181	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MT995_RS07435	1494239..1494526	-	288	WP_001040261.1	hypothetical protein	-
MT995_RS07440	1494573..1494725	-	153	WP_001153681.1	hypothetical protein	-
MT995_RS07445	1494715..1498500	-	3786	WP_000582158.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1489797..1540644	50847

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T239982 WP_011447039.1 NZ_CP094663:c1493735-1493559 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T239982 NZ_LS483429:47730-48128 [Haemophilus aegyptius]
GTGTTGAAATATATGCTTGATACTAACATTGTGATTTACGTGATTAAGCGTAGGCCATTGGAAATTCTTTCTCGCTTTAA
TCAAAATGCAGGAAAAATGTGCGTGAGTAGCATTACTGTGGCTGAACTCTATTATGGAGCTGAAAAAAGCGAATATCCCG
AAAGAAACATTGCGGTTATTGAAGATTTCTTATCACGCCTCACCATTTTAGATTACCAACCAAAGCATGCAGCTCATTTC
GGCAATATTAAAGCTGAACTCTCTAAACAAGGGAAATTGATTGGCGAAAATGATATTCATATAGCTGCTCATGCTCGTAG
TGAAGGGTTAATTCTGGTTAGTAACAATTTAAGAGAATTTGAGCGAGTTATAGCATTACGTACAGAAAATTGGGTGTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT239982 NZ_CP094663:1493436-1493491 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin