Detailed information of TA system TA239981

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1493428..1493735
• Replicon: chromosome
• Accession: NZ_CP094663
• Organism: Staphylococcus aureus strain 494

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MT995_RS07425
• Protein ID: WP_011447039.1
• Coordinates: 1493559..1493735 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1493428..1493567 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT995_RS07385 (1488994)	1488994..1489173	+	180	WP_000669789.1	hypothetical protein	-
MT995_RS07390 (1489484)	1489484..1489744	+	261	WP_001791826.1	hypothetical protein	-
MT995_RS07395 (1489797)	1489797..1490147	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
MT995_RS07400 (1490658)	1490658..1490993	-	336	Protein_1428	SH3 domain-containing protein	-
MT995_RS07405 (1491644)	1491644..1492135	-	492	WP_000920038.1	staphylokinase	-
MT995_RS07410 (1492326)	1492326..1493081	-	756	WP_000861038.1	CHAP domain-containing protein	-
MT995_RS07415 (1493093)	1493093..1493347	-	255	WP_000611512.1	phage holin	-
MT995_RS07420 (1493399)	1493399..1493506	+	108	WP_001791821.1	hypothetical protein	-
- (1493428)	1493428..1493567	+	140	NuclAT_0	-	Antitoxin
- (1493428)	1493428..1493567	+	140	NuclAT_0	-	Antitoxin
- (1493428)	1493428..1493567	+	140	NuclAT_0	-	Antitoxin
- (1493428)	1493428..1493567	+	140	NuclAT_0	-	Antitoxin
MT995_RS07425 (1493559)	1493559..1493735	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
MT995_RS07430 (1493885)	1493885..1494181	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MT995_RS07435 (1494239)	1494239..1494526	-	288	WP_001040261.1	hypothetical protein	-
MT995_RS07440 (1494573)	1494573..1494725	-	153	WP_001153681.1	hypothetical protein	-
MT995_RS07445 (1494715)	1494715..1498500	-	3786	WP_000582158.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / sak / hlb / groEL	1489797..1540644	50847

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T239981 WP_011447039.1 NZ_CP094663:c1493735-1493559 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T239981 NZ_LS483426:979369-979638 [Kingella kingae]
ATGAGCAGAGAAATTATTTTTCAAGGGCAGTTTAAGCGAGATGTGAAAAAGCAGTTTTTAGAGCTTGCGACAGTGGAATG
GGCAGAAGTTTTAACTTGTTTGGTAAATGATTTGCCGCTTGCTGAAAAATATCGCGACCATGCGCTTGTGAATGACAAAA
ACGGATACAGAGACTGCCATATCAAGCCTGATTTGGTTTTAATTTACGGCAGGAAAGAAAACGCCTTGATACTTGTTCGG
TTAGGTTCTCATTCCGAGATATTTGGCTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT239981 NZ_CP094663:1493428-1493567 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin