Detailed information of TA system TA239962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2786882..2787533
• Replicon: chromosome
• Accession: NZ_CP094620
• Organism: Acinetobacter sp. NyZ410

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MTO68_RS13145
• Protein ID: WP_151802360.1
• Coordinates: 2787177..2787533 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MTO68_RS13140
• Protein ID: WP_244012813.1
• Coordinates: 2786882..2787184 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTO68_RS13125 (MTO68_13125)	2782848..2784575	+	1728	Protein_2578	TonB-dependent siderophore receptor	-
MTO68_RS13130 (MTO68_13130)	2784636..2784914	+	279	WP_244012809.1	hypothetical protein	-
MTO68_RS13135 (MTO68_13135)	2784918..2786480	+	1563	WP_244012811.1	PepSY-associated TM helix domain-containing protein	-
MTO68_RS13140 (MTO68_13140)	2786882..2787184	-	303	WP_244012813.1	XRE family transcriptional regulator	Antitoxin
MTO68_RS13145 (MTO68_13145)	2787177..2787533	-	357	WP_151802360.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTO68_RS13150 (MTO68_13150)	2787931..2789802	+	1872	WP_167321166.1	ABC transporter ATP-binding protein	-
MTO68_RS13155 (MTO68_13155)	2790181..2791329	-	1149	WP_004822164.1	phospholipase A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-81)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13552.61 Da
• Isoelectric Point: 6.4642

>T239962 WP_151802360.1 NZ_CP094620:c2787533-2787177 [Acinetobacter sp. NyZ410]
MWTVITTDLFNEWLEQQDDSTQEKVLAALVVLQQLGPSLGRPLVDTVNDSKFMNMKELRVQHRGKPLRAFFIFDPLRQAI
VLCIGNKGGKKRFYKEMLDIAEQQYELHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T239962 NZ_LS483421:1538659-1538994 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAAGTTTTCCGAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11389.20 Da
• Isoelectric Point: 6.7300

>AT239962 WP_244012813.1 NZ_CP094620:c2787184-2786882 [Acinetobacter sp. NyZ410]
MAKTLQELLASRSPESQDRIQKMADELRLQTQLHLIREELEISQKELAEILGIKQPSLSAIENRGHDLKISTIKKYVEAM
GGKLRIDVELPTGKHIEFNV

Nucleotide

• Length: 303 bp

>AT239962 NZ_LS483421:1538382-1538669 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA