Detailed information of TA system TA239956

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 45875..46460
• Replicon: chromosome
• Accession: NZ_CP094555
• Organism: Acinetobacter sp. YH12068_T

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3F3L0E6
• Locus tag: MST18_RS00200
• Protein ID: WP_002126330.1
• Coordinates: 46140..46460 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MST18_RS00195
• Protein ID: WP_004676016.1
• Coordinates: 45875..46147 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST18_RS00170 (MST18_00170)	41737..43059	+	1323	WP_180134001.1	hypothetical protein	-
MST18_RS00175 (MST18_00175)	43040..43327	+	288	WP_180134000.1	chorismate mutase	-
MST18_RS00180 (MST18_00180)	43397..44731	-	1335	WP_016658832.1	ISNCY family transposase	-
MST18_RS00185 (MST18_00185)	45102..45278	+	177	Protein_31	transposase	-
MST18_RS00190 (MST18_00190)	45299..45679	+	381	WP_168417344.1	hypothetical protein	-
MST18_RS00195 (MST18_00195)	45875..46147	-	273	WP_004676016.1	NadS family protein	Antitoxin
MST18_RS00200 (MST18_00200)	46140..46460	-	321	WP_002126330.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MST18_RS00205 (MST18_00205)	46608..47948	-	1341	WP_180133351.1	ISNCY family transposase	-
MST18_RS00210 (MST18_00210)	48129..48737	-	609	WP_180133350.1	NAD(P)H-dependent oxidoreductase	-
MST18_RS00215 (MST18_00215)	48836..49747	+	912	WP_180128562.1	LysR family transcriptional regulator	-
MST18_RS00220 (MST18_00220)	50127..50864	+	738	WP_180133349.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	43397..47948	4551

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12191.98 Da
• Isoelectric Point: 7.9834

>T239956 WP_002126330.1 NZ_CP094555:c46460-46140 [Acinetobacter sp. YH12068_T]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVNEDDQIFFLVAY
PKSVKDNLTDKETAILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T239956 NZ_LS483418:594447-594716 [Streptococcus suis]
ATGGCTTATAAGCTTGTTCTCAGCGATGATGCTTTGAAGCAGTTGAAAAAAATGGACAGGCATGTGGGGATGATGCTTGC
TAAGGATTTGAAAAAACGTTTGGACGGTTTGGAGAATCCAAGACAATTTGGGAAGGCCTTGGTAGGAGACTATAAGGGGC
TGTGGCGGTATAGAGTGGGGAATTACCGTGTAATTTGTGATATTATTGATAACAAAATGGTCATCCTGGCCCTTGAAATC
GGGCACCGGAAAGAAATCTATAAAAAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10178.56 Da
• Isoelectric Point: 7.3200

>AT239956 WP_004676016.1 NZ_CP094555:c46147-45875 [Acinetobacter sp. YH12068_T]
MDNNLFDDLVASIKEAGAIKRKEIQASRTTELELPDIKEVREKTGLSQSEFAARLHISHRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Nucleotide

• Length: 273 bp

>AT239956 NZ_LS483418:594230-594457 [Streptococcus suis]
ATGGGAATTGTATCCTTGCGATTAAACGATGCAGAAGAAGAAATTTTCAGAAGCTATGCTATTCATACAGGAAAAAGCCT
GTCTGAGCTATTCAAAACTGCACTTGCTGAACAGATAGAAGACCAGTTGGACTATGAAATTGGTATCAAGGCTTTGAAGA
AATTCCAAGAAAATCCTGTTACACACTCGATTGATGATGTTCTTGCGGAGTTAGAAGATGGCTTATAA

Structures

Toxin

• AlphaFold DB: A0A3F3L0E6