Detailed information of TA system TA239955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 3171167..3171752
• Replicon: chromosome
• Accession: NZ_CP094545
• Organism: Acinetobacter sp. YH16056_T

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1A7RA20
• Locus tag: MST17_RS15410
• Protein ID: WP_067765721.1
• Coordinates: 3171432..3171752 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MST17_RS15405
• Protein ID: WP_004641921.1
• Coordinates: 3171167..3171439 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST17_RS15375 (MST17_15350)	3166895..3167839	-	945	WP_078190578.1	glutathione synthase	-
MST17_RS15380 (MST17_15355)	3168167..3169069	+	903	WP_180025891.1	sensor domain-containing diguanylate cyclase	-
MST17_RS15385 (MST17_15360)	3169195..3169392	+	198	WP_180025890.1	DUF3565 domain-containing protein	-
MST17_RS15390 (MST17_15365)	3169449..3169976	+	528	WP_000537572.1	plasmid pRiA4b ORF-3 family protein	-
MST17_RS15395 (MST17_15370)	3170082..3170330	+	249	WP_044425274.1	type II toxin-antitoxin system HicA family toxin	-
MST17_RS15400 (MST17_15375)	3170327..3170662	+	336	WP_035270373.1	type II toxin-antitoxin system HicB family antitoxin	-
MST17_RS15405 (MST17_15380)	3171167..3171439	-	273	WP_004641921.1	NadS family protein	Antitoxin
MST17_RS15410 (MST17_15385)	3171432..3171752	-	321	WP_067765721.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MST17_RS15415 (MST17_15390)	3172003..3172227	+	225	WP_100329926.1	hypothetical protein	-
MST17_RS15420 (MST17_15395)	3172518..3173168	-	651	WP_078190583.1	orotate phosphoribosyltransferase	-
MST17_RS15425 (MST17_15400)	3173209..3174027	+	819	WP_180025889.1	exodeoxyribonuclease III	-
MST17_RS15430 (MST17_15405)	3174653..3175000	+	348	WP_180025888.1	Spx/MgsR family RNA polymerase-binding regulatory protein	-
MST17_RS15435 (MST17_15410)	3175105..3175542	-	438	WP_078190586.1	DUF2147 domain-containing protein	-
MST17_RS15440 (MST17_15415)	3175698..3176609	+	912	WP_180025887.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12225.01 Da
• Isoelectric Point: 7.9835

>T239955 WP_067765721.1 NZ_CP094545:c3171752-3171432 [Acinetobacter sp. YH16056_T]
MLFIETSVFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCTQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T239955 NZ_LS483417:c1633562-1633383 [Streptococcus pneumoniae]
ATACCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10108.56 Da
• Isoelectric Point: 7.2045

>AT239955 WP_004641921.1 NZ_CP094545:c3171439-3171167 [Acinetobacter sp. YH16056_T]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Nucleotide

• Length: 273 bp

>AT239955 NZ_LS483417:c1633346-1632894 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Structures

Toxin

• AlphaFold DB: A0A1A7RA20