Detailed information of TA system TA239948

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 132092..132677
• Replicon: chromosome
• Accession: NZ_CP094541
• Organism: Acinetobacter sp. YH16040_T

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A1A7RA20
• Locus tag: MST16_RS00660
• Protein ID: WP_067765721.1
• Coordinates: 132357..132677 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MST16_RS00655
• Protein ID: WP_004641921.1
• Coordinates: 132092..132364 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MST16_RS00630 (MST16_00630)	128005..128823	-	819	WP_078193225.1	exodeoxyribonuclease III	-
MST16_RS00635 (MST16_00635)	128864..129514	+	651	WP_078190583.1	orotate phosphoribosyltransferase	-
MST16_RS00640 (MST16_00640)	129783..130310	+	528	WP_000537572.1	plasmid pRiA4b ORF-3 family protein	-
MST16_RS00645 (MST16_00645)	130416..130664	+	249	WP_044425274.1	type II toxin-antitoxin system HicA family toxin	-
MST16_RS00650 (MST16_00650)	130661..130996	+	336	WP_035270373.1	type II toxin-antitoxin system HicB family antitoxin	-
MST16_RS00655 (MST16_00655)	132092..132364	-	273	WP_004641921.1	NadS family protein	Antitoxin
MST16_RS00660 (MST16_00660)	132357..132677	-	321	WP_067765721.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MST16_RS00665 (MST16_00665)	132928..133152	+	225	WP_100329926.1	hypothetical protein	-
MST16_RS00670 (MST16_00670)	133353..134678	+	1326	WP_180012554.1	ISNCY family transposase	-
MST16_RS00675 (MST16_00675)	134729..134914	-	186	Protein_129	DUF3565 domain-containing protein	-
MST16_RS00680 (MST16_00680)	135040..135942	-	903	WP_180008762.1	sensor domain-containing diguanylate cyclase	-
MST16_RS00685 (MST16_00685)	136266..137210	+	945	WP_180008764.1	glutathione synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	133341..134678	1337

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12225.01 Da
• Isoelectric Point: 7.9835

>T239948 WP_067765721.1 NZ_CP094541:c132677-132357 [Acinetobacter sp. YH16040_T]
MLFIETSVFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCTQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T239948 NZ_LS483411:c1504848-1504585 [Haemophilus influenzae]
ATGATTTCAGTGAGTGAGGAATATAAAAGAGAATTTAAAAAACATATTCCTCTTATTATAAATAGTCCAGAATATATTGA
AGTTATGTATTGTCTTTTGAATAGCTTACCATTGCCAGAAAAATATAAAGATCACGCTTTAACTGGCAATTGGAAAGGTT
GGCGAGATTGCCATATTAAGAATGATCTCGTGCTTATTTATAAAATTGTGGGGGATGAAATAAGACTAGCTCGTCTTAAT
ACCCATCCAGAAATTTTTGGTTAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10108.56 Da
• Isoelectric Point: 7.2045

>AT239948 WP_004641921.1 NZ_CP094541:c132364-132092 [Acinetobacter sp. YH16040_T]
MDNNLFDDLVASIKEAGAIKRNEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Nucleotide

• Length: 273 bp

>AT239948 NZ_LS483411:c1505120-1504845 [Haemophilus influenzae]
ATGGCTGCAGTTAGCTTTCGAGTACCTGATGAAACTAAAAATATAGCGTTTGAAGTGATTAAAAGTTATGGTCTTTCCCC
AACTCAAGCACTTAATATGTTTTTAGCTCAAATAGCTAAAACGAAAGCGATTCCAGTATCATTAGATTATCAAACTGAAC
AGATGCCTAACTCAAAAACGATAATGGCTATGGCAGAGTTGGATAATCATAATGGGCGTGAATACAAAACATTGGAGGAA
TTCCATCAAGCGATGCTATCGGAGATGAAACTATGA

Structures

Toxin

• AlphaFold DB: A0A1A7RA20