Detailed information of TA system TA239907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 350765..351411
• Replicon: chromosome
• Accession: NZ_CP094512
• Organism: Klebsiella pneumoniae strain SHX180

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MTX44_RS01615
• Protein ID: WP_064158923.1
• Coordinates: 350765..351112 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A1F2LZT5
• Locus tag: MTX44_RS01620
• Protein ID: WP_008806992.1
• Coordinates: 351112..351411 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX44_RS01605 (MTX44_01605)	346691..348124	+	1434	WP_002920564.1	glycogen synthase GlgA	-
MTX44_RS01610 (MTX44_01610)	348142..350589	+	2448	WP_029884517.1	glycogen phosphorylase	-
MTX44_RS01615 (MTX44_01615)	350765..351112	+	348	WP_064158923.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MTX44_RS01620 (MTX44_01620)	351112..351411	+	300	WP_008806992.1	XRE family transcriptional regulator	Antitoxin
MTX44_RS01625 (MTX44_01625)	351474..352982	-	1509	WP_002920554.1	glycerol-3-phosphate dehydrogenase	-
MTX44_RS01630 (MTX44_01630)	353187..353516	+	330	WP_002920552.1	thiosulfate sulfurtransferase GlpE	-
MTX44_RS01635 (MTX44_01635)	353567..354397	+	831	WP_004151408.1	rhomboid family intramembrane serine protease GlpG	-
MTX44_RS01640 (MTX44_01640)	354447..355205	+	759	WP_002920548.1	DeoR/GlpR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (31-84)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13597.64 Da
• Isoelectric Point: 6.2327

>T239907 WP_064158923.1 NZ_CP094512:350765-351112 [Klebsiella pneumoniae]
MWYVETTDTFDTWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGDKDGMNEKRFYKEMITLADREFSQHLTKER

Nucleotide

• Length: 348 bp

>T239907 NZ_LS483392:c183906-183628 [Haemophilus influenzae]
ATGTACGCGATTGCTTTTGATTTAGTTGTAAAAGACACTCAAGATTATCATCCAAAAGGTGTTCAGCAGGCTTATACAGA
CATTGGTGCGGTTTTAGCAAAATTTGGTTTTGTTAGAACACAAGGAAGTTTATATACCAATACAAATGAAGATATGGCAA
ACCTTTTTCAGGCAATGAATTCGCTAAAACAGTTGGCGTGGATTTCTCAGTCGGTACGAGATATTCGTGCTTTTCGTATT
GAGCAATGGTCTGACTTCACTGACTTTATACGAAGTTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10814.61 Da
• Isoelectric Point: 10.1464

>AT239907 WP_008806992.1 NZ_CP094512:351112-351411 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Nucleotide

• Length: 300 bp

>AT239907 NZ_LS483392:c184106-183915 [Haemophilus influenzae]
ATGGAACTAAGACAACAAATTCCAACGGGCTGTATTAAACAATTCGGGCAATTTGGCGTGCCTTATGTGGTTGGCGAGGT
TGCGGAATTTTTGCCAGATGGCGATGCGTTGGTAAATATCACATTGTTACAATCTGGAGAAAAAGATATTTATCGCTTAT
CTCACTTACTTGAAGATCCCGAAGCTGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A1F2LZT5