239905

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 1350..1980 Replicon plasmid ps02
Accession NZ_CP094481
Organism Klebsiella pneumoniae strain LXR-1

Toxin (Protein)


Gene name higB Uniprot ID A0A3V9PY09
Locus tag MST28_RS26960 Protein ID WP_001708474.1
Coordinates 1645..1980 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A704FLZ1
Locus tag MST28_RS26955 Protein ID WP_001708475.1
Coordinates 1350..1640 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MST28_RS26950 (MST28_26950) 637..1290 - 654 WP_243440445.1 hypothetical protein -
MST28_RS26955 (MST28_26955) 1350..1640 - 291 WP_001708475.1 NadS family protein Antitoxin
MST28_RS26960 (MST28_26960) 1645..1980 - 336 WP_001708474.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MST28_RS26965 (MST28_26965) 2183..2824 - 642 WP_099032891.1 hypothetical protein -
MST28_RS26970 (MST28_26970) 2897..3223 - 327 WP_064163824.1 hypothetical protein -
MST28_RS26975 (MST28_26975) 3536..4096 - 561 WP_070558864.1 hypothetical protein -
MST28_RS26980 (MST28_26980) 4114..4464 - 351 WP_085674785.1 hypothetical protein -
MST28_RS26985 (MST28_26985) 4461..4730 - 270 WP_024172976.1 hypothetical protein -
MST28_RS26990 (MST28_26990) 4744..5121 - 378 WP_219990149.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..43173 43173


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-104)

Antitoxin

Antitoxin MqsA/HigA-2

(21-94)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12615.30 Da        Isoelectric Point: 5.2407

>T239905 WP_001708474.1 NZ_CP094481:c1980-1645 [Klebsiella pneumoniae]
MEYYEFVETSVFTREMKTLLSDDEYKEFQTFLIENPEAGDLIVGTGGCRKVRWSRQGTGKSSGVRAIYYFYNPAGRLYML
IIYPKSEKDSLTAAEKNQLKAVVAGFKGEEG

Download         Length: 336 bp

>T239905 NZ_LS483390:c1589381-1589202 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10909.62 Da        Isoelectric Point: 10.0073

>AT239905 WP_001708475.1 NZ_CP094481:c1640-1350 [Klebsiella pneumoniae]
MRKELFDDLIASAKEAVEIHQGLREPARVTRFERPDVKAIRAKVHMKQDDFASLIGVSSSLVQSWEQGLRTPAGAALKLL
RVIERKPEFVQELREA

Download         Length: 291 bp

>AT239905 NZ_LS483390:c1589165-1588713 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATTAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACTATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V9PY09

Antitoxin

Source ID Structure
AlphaFold DB A0A704FLZ1

References