Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 343029..343615 Replicon chromosome
Accession NZ_CP094479
Organism Klebsiella pneumoniae strain LXR-1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag MST28_RS01615 Protein ID WP_002920800.1
Coordinates 343247..343615 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag MST28_RS01610 Protein ID WP_004174006.1
Coordinates 343029..343250 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MST28_RS01590 (339186) 339186..340112 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MST28_RS01595 (340109) 340109..341386 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
MST28_RS01600 (341383) 341383..342150 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MST28_RS01605 (342152) 342152..342865 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
MST28_RS01610 (343029) 343029..343250 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MST28_RS01615 (343247) 343247..343615 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MST28_RS01620 (343888) 343888..345204 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
MST28_RS01625 (345311) 345311..346198 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
MST28_RS01630 (346195) 346195..347040 + 846 WP_004145129.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
MST28_RS01635 (347042) 347042..348112 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 341383..348849 7466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T239882 WP_002920800.1 NZ_CP094479:343247-343615 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T239882 NZ_LS483377:c693716-692967 [Stenotrophomonas maltophilia]
CTGCTCTACCGACTCTCCGCTTCCCGATACCGCGACCAGTTCCTGCTGAAGGGCGCCATGTTGTTTGCAGTGTGGTTCGA
CGCGCCCCACCGTCCCACGCGGGATGCCGATTTTCTGCGATTCGGCTCTGCAGATCCCGACCATCTGCTGCACATCGCAC
GGTCGCTCTGTGCAATACCGGACGACGACGGCCTATGCTTCGACCCGGGCAGCATCGCCATCGAGGCCACCCGCGAAGAA
GCGGAGTATGAGGGGTTGCGAATCCGCCTGACCGCACATCTTGGCCGCTCGCGCTGCCACGTACAGTGGGACGTGGGGTT
TGGCGATGCGGTGACTCCCCCACCGCCGGAAATCGCCTACCCGGTGATGCTGGATGGCTTTCCTCTCCCCTGCCTGCACG
TCTATCCGCGCGAGACCGTGTTTGCCGAAAAGCTGGAGGCCATTGCGGCACTGGGCATCGCAAACAGCAGGATGAAGGAC
TTCTTCGACTTGCTGGCACTGGTCCGCGAAGACGCCATGGATCGTCCACACCTTGTTGCGGCCATTGGCGCGACGTTTGA
TCGGCGAGGGACCCCGGCGCCGCCCCCCTTGCCCTACGGACTGACACAGTCGTTCGCCGCAGATACCCAGAAGCAGACCC
AGTGGCGCGCCTTCCTGCGCAGGAATCGCCTGATCGCGCCGGATCTCTCTTCGGTGATTGCCGAGATTGCCGACTATCTG
GACACCCTCGACACAACCGTACAGTCCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT239882 WP_004174006.1 NZ_CP094479:343029-343250 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT239882 NZ_LS483377:c694435-693833 [Stenotrophomonas maltophilia]
ATGGGAAACGCCGAGGCCAACGCACGAAAGCTGTTGCGACGCGCAGGCACCCTGCGCGCCCGCGAGCTGGTGACCGCCGG
GATCGCCCGCGCCCAGCTGACCCGACTGGTCGAGGCCGGTGCGCTGATCCGGCTGTCTCGTGGCGTCTACGCGTTGGCGG
AAAGAAACAGTGACGACACCGATGATGGACTGCGGATCATTGCCGAACGCCTGCCGCACCCCCGTCTGTGCCTGTTGAGT
GCCCTGCGCCTGCATGGCCTGACCACCCAGGCGCCATTCGAACGCTGGGTCTCCATCGGCAACAGCGACCGCGTTCCGCG
GATCGATTGGCCGCCCCTCCGAGTGGTCCGCATGTCGGCAAAGACCCTCAACGCGGGGCTGGAAGAGCGTCGCGTAGGCA
AACGTCTCATATACGTCAGCAATGTGGCCAAAACCGTCGTCGATTGCTTCAAGTTCCGCAATCTCGTAGGACTTGATGTC
GCAATTGAAGCCCTGCGTGACGCGCTTCACAGCCGTGCGACCACGCCGGATGCGCTGATGGAGTATGCGCGGATCTGCCG
CGTTGCCAGACTGATGAGACCGTACCTCGATGCCCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References