Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 2461006..2461621 Replicon chromosome
Accession NZ_CP094460
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MRS60_RS27905 Protein ID WP_243565994.1
Coordinates 2461280..2461621 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MRS60_RS27900 Protein ID WP_034181868.1
Coordinates 2461006..2461293 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS27865 (MRS60_27865) 2456333..2456626 + 294 WP_243565992.1 hypothetical protein -
MRS60_RS27870 (MRS60_27870) 2456559..2457338 - 780 WP_034181865.1 5'/3'-nucleotidase SurE -
MRS60_RS27875 (MRS60_27875) 2457662..2457969 - 308 Protein_2195 AzlD family protein -
MRS60_RS27880 (MRS60_27880) 2457962..2458696 - 735 WP_027789977.1 AzlC family ABC transporter permease -
MRS60_RS27885 (MRS60_27885) 2458823..2459281 + 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
MRS60_RS27890 (MRS60_27890) 2459502..2460071 + 570 WP_027789976.1 hypothetical protein -
MRS60_RS27895 (MRS60_27895) 2460237..2460926 + 690 WP_243565993.1 YebB family permuted papain-like enzyme -
MRS60_RS27900 (MRS60_27900) 2461006..2461293 - 288 WP_034181868.1 helix-turn-helix transcriptional regulator Antitoxin
MRS60_RS27905 (MRS60_27905) 2461280..2461621 - 342 WP_243565994.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MRS60_RS27910 (MRS60_27910) 2461837..2462469 - 633 WP_217588583.1 LysE family translocator -
MRS60_RS27915 (MRS60_27915) 2462763..2464535 + 1773 WP_243565995.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13074.20 Da        Isoelectric Point: 9.8553

>T239870 WP_243565994.1 NZ_CP094460:c2461621-2461280 [Burkholderia pyrrocinia]
MRTVADEIHFFSEQVEAGVFALPKTLTARFFALADRMEQYGPNPGEPHTRPMGDGLYEMRLKGLEGIARVFYCAVVNRRI
VMLHCFVNKTQKTPQKELETARRRLKEIRYGNL

Download         Length: 342 bp

>T239870 NZ_LS483367:c272624-272289 [Streptococcus dysgalactiae subsp. equisimilis]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCCCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAATGACATAGAAAAACTTGAAGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAGAAATCAGCAATTATCACAGTACTAGAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAAGAGGAAGAGAATAGGGTTGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
GAAATTGTTTAAATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10405.07 Da        Isoelectric Point: 10.4476

>AT239870 WP_034181868.1 NZ_CP094460:c2461293-2461006 [Burkholderia pyrrocinia]
MATYKALRERALADPKVRAEYERLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIETLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT239870 NZ_LS483367:c272901-272614 [Streptococcus dysgalactiae subsp. equisimilis]
ATGGTTACAGCAGAAAAAAATAGAGCTGTCACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCCGAAATCAGCAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References