Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 787982..788682 Replicon chromosome
Accession NZ_CP094460
Organism Burkholderia pyrrocinia strain JK-SH007

Toxin (Protein)


Gene name mqsR Uniprot ID A0A2S8IM05
Locus tag MRS60_RS20310 Protein ID WP_034180144.1
Coordinates 787982..788278 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A2U9SYM3
Locus tag MRS60_RS20315 Protein ID WP_034180145.1
Coordinates 788281..788682 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRS60_RS20295 (MRS60_20295) 784493..786043 + 1551 WP_034180141.1 sensor domain-containing diguanylate cyclase -
MRS60_RS20300 (MRS60_20300) 786301..786573 + 273 WP_243566858.1 hypothetical protein -
MRS60_RS20305 (MRS60_20305) 786839..787873 + 1035 WP_175747743.1 succinylglutamate desuccinylase/aspartoacylase family protein -
MRS60_RS20310 (MRS60_20310) 787982..788278 + 297 WP_034180144.1 type II toxin-antitoxin system MqsR family toxin Toxin
MRS60_RS20315 (MRS60_20315) 788281..788682 + 402 WP_034180145.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
MRS60_RS20320 (MRS60_20320) 788991..789551 + 561 WP_243566533.1 GNAT family N-acetyltransferase -
MRS60_RS20325 (MRS60_20325) 789605..790546 + 942 WP_131948954.1 ABC transporter substrate-binding protein -
MRS60_RS20330 (MRS60_20330) 790600..791649 + 1050 WP_243566534.1 LLM class flavin-dependent oxidoreductase -
MRS60_RS20335 (MRS60_20335) 791657..793009 + 1353 WP_243566535.1 LLM class flavin-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(6-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11140.85 Da        Isoelectric Point: 9.4833

>T239864 WP_034180144.1 NZ_CP094460:787982-788278 [Burkholderia pyrrocinia]
MEKNSAHCKLSRIKTLIENGKVRLTASAVFGARQLGFTEREAVGVVMSLTAADFYKSMTTYADHTIWQDVYQRRTVHGDV
YLKLTVIDDVLIVSFKER

Download         Length: 297 bp

>T239864 NZ_LS483365:c2143925-2143563 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14660.93 Da        Isoelectric Point: 8.4816

>AT239864 WP_034180145.1 NZ_CP094460:788281-788682 [Burkholderia pyrrocinia]
MKCPACGAAKLVRDTRDIPYTYKGRSTVVRDITGDFCPACGESVLDLDEATRLGDAITEFNKQVNSTIVDPKYIAKVRKK
LMLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLFKILDRHPDLLAEVRAA

Download         Length: 402 bp

>AT239864 NZ_LS483365:c2144092-2143922 [Staphylococcus aureus subsp. aureus NCTC 8325]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S8IM05

Antitoxin

Source ID Structure
AlphaFold DB A0A2U9SYM3

References