Detailed information of TA system TA239850

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 45921..46347
• Replicon: plasmid pKP4831-2
• Accession: NZ_CP094453
• Organism: Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MRR30_RS29430
• Protein ID: WP_001372321.1
• Coordinates: 45921..46046 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	46123..46347 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRR30_RS29405 (42174)	42174..42557	-	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MRR30_RS29410 (42834)	42834..43481	+	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
MRR30_RS29415 (43778)	43778..44599	-	822	WP_001234445.1	DUF932 domain-containing protein	-
MRR30_RS29420 (44710)	44710..45006	-	297	WP_001272251.1	hypothetical protein	-
MRR30_RS29425 (45306)	45306..45602	+	297	Protein_54	hypothetical protein	-
MRR30_RS29430 (45921)	45921..46046	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
MRR30_RS29435 (45988)	45988..46137	-	150	Protein_56	plasmid maintenance protein Mok	-
- (46123)	46123..46347	-	225	NuclAT_0	-	Antitoxin
- (46123)	46123..46347	-	225	NuclAT_0	-	Antitoxin
- (46123)	46123..46347	-	225	NuclAT_0	-	Antitoxin
- (46123)	46123..46347	-	225	NuclAT_0	-	Antitoxin
MRR30_RS29440 (46359)	46359..47078	-	720	WP_001276217.1	plasmid SOS inhibition protein A	-
MRR30_RS29445 (47075)	47075..47509	-	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
MRR30_RS29450 (47578)	47578..49601	-	2024	Protein_59	ParB/RepB/Spo0J family partition protein	-
MRR30_RS29455 (49662)	49662..49895	-	234	WP_000006003.1	DUF905 family protein	-
MRR30_RS29460 (49953)	49953..50480	-	528	WP_000290834.1	single-stranded DNA-binding protein	-
MRR30_RS29465 (50782)	50782..51225	+	444	Protein_62	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	blaSHV-12 / blaKPC-2 / rmtB / blaTEM-1B	-	1..96608	96608

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T239850 WP_001372321.1 NZ_CP094453:c46046-45921 [Klebsiella pneumoniae subsp. rhinoscleromatis]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T239850 NZ_LS483358:c1557010-1556639 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGCCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Nucleotide

• Length: 225 bp

>AT239850 NZ_CP094453:c46347-46123 [Klebsiella pneumoniae subsp. rhinoscleromatis]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin