Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 742195..742970 Replicon chromosome
Accession NZ_CP094451
Organism Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag MRR30_RS03710 Protein ID WP_004150910.1
Coordinates 742485..742970 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag MRR30_RS03705 Protein ID WP_004150912.1
Coordinates 742195..742488 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRR30_RS03685 (MRR30_03685) 737403..738005 - 603 WP_062954968.1 short chain dehydrogenase -
MRR30_RS03690 (MRR30_03690) 738103..739014 + 912 WP_004188550.1 LysR family transcriptional regulator -
MRR30_RS03695 (MRR30_03695) 739015..740163 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
MRR30_RS03700 (MRR30_03700) 740174..741550 - 1377 WP_004217775.1 cystathionine beta-synthase -
MRR30_RS03705 (MRR30_03705) 742195..742488 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
MRR30_RS03710 (MRR30_03710) 742485..742970 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
MRR30_RS03715 (MRR30_03715) 743674..744267 + 594 WP_004188553.1 hypothetical protein -
MRR30_RS03720 (MRR30_03720) 744364..744580 + 217 Protein_732 transposase -
MRR30_RS03725 (MRR30_03725) 745203..746075 + 873 WP_172593510.1 ParA family protein -
MRR30_RS03730 (MRR30_03730) 746153..746584 - 432 WP_001095747.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 744364..744516 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T239833 WP_004150910.1 NZ_CP094451:742485-742970 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

>T239833 NZ_LS483350:c2019706-2019530 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTCATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT239833 WP_004150912.1 NZ_CP094451:742195-742488 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp

>AT239833 NZ_LS483350:2019407-2019462 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References