Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 354988..355634 Replicon chromosome
Accession NZ_CP094451
Organism Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag MRR30_RS01640 Protein ID WP_002920560.1
Coordinates 354988..355335 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag MRR30_RS01645 Protein ID WP_002920557.1
Coordinates 355335..355634 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRR30_RS01630 (MRR30_01630) 350914..352347 + 1434 WP_002920564.1 glycogen synthase GlgA -
MRR30_RS01635 (MRR30_01635) 352365..354812 + 2448 WP_002920561.1 glycogen phosphorylase -
MRR30_RS01640 (MRR30_01640) 354988..355335 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MRR30_RS01645 (MRR30_01645) 355335..355634 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
MRR30_RS01650 (MRR30_01650) 355697..357205 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
MRR30_RS01655 (MRR30_01655) 357410..357739 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
MRR30_RS01660 (MRR30_01660) 357790..358620 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
MRR30_RS01665 (MRR30_01665) 358670..359428 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T239832 WP_002920560.1 NZ_CP094451:354988-355335 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T239832 NZ_LS483350:c1917104-1916952 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT239832 WP_002920557.1 NZ_CP094451:355335-355634 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT239832 NZ_LS483350:c1917728-1917129 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References