Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 328799..329385 Replicon chromosome
Accession NZ_CP094451
Organism Klebsiella pneumoniae subsp. rhinoscleromatis strain KP4831

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag MRR30_RS01530 Protein ID WP_002920800.1
Coordinates 329017..329385 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag MRR30_RS01525 Protein ID WP_002920802.1
Coordinates 328799..329020 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRR30_RS01505 (MRR30_01505) 324956..325882 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MRR30_RS01510 (MRR30_01510) 325879..327156 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
MRR30_RS01515 (MRR30_01515) 327153..327920 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MRR30_RS01520 (MRR30_01520) 327922..328635 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
MRR30_RS01525 (MRR30_01525) 328799..329020 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MRR30_RS01530 (MRR30_01530) 329017..329385 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MRR30_RS01535 (MRR30_01535) 329658..330974 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
MRR30_RS01540 (MRR30_01540) 331081..331968 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
MRR30_RS01545 (MRR30_01545) 331965..332810 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
MRR30_RS01550 (MRR30_01550) 332812..333882 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 327153..334619 7466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T239831 WP_002920800.1 NZ_CP094451:329017-329385 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T239831 NZ_LS483350:1860356-1860451 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT239831 WP_002920802.1 NZ_CP094451:328799-329020 [Klebsiella pneumoniae subsp. rhinoscleromatis]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT239831 NZ_LS483350:c1860538-1860479 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References