Detailed information of TA system TA239823

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2740438..2740716
• Replicon: chromosome
• Accession: NZ_CP094443
• Organism: Staphylococcus aureus strain N10CSA27

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: MTP23_RS13660
• Protein ID: WP_001802298.1
• Coordinates: 2740438..2740542 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2740538..2740716 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP23_RS13640	2737235..2738017	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
MTP23_RS13645	2738085..2738942	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
MTP23_RS13650	2739600..2739758	-	159	WP_001792784.1	hypothetical protein	-
MTP23_RS13655	2739751..2739921	-	171	WP_001792292.1	transposase	-
MTP23_RS13660	2740438..2740542	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2740538..2740716	-	179	-	-	Antitoxin
MTP23_RS13670	2740975..2742066	-	1092	WP_000495669.1	hypothetical protein	-
MTP23_RS13675	2742332..2743309	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
MTP23_RS13680	2743311..2743631	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
MTP23_RS13685	2743783..2744448	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-106)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T239823 WP_001802298.1 NZ_CP094443:2740438-2740542 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T239823 NZ_LS483347:1663383-1663718 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT239823 NZ_CP094443:c2740716-2740538 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin