Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2480629..2481146 Replicon chromosome
Accession NZ_CP094443
Organism Staphylococcus aureus strain N10CSA27

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag MTP23_RS12300 Protein ID WP_000113265.1
Coordinates 2480880..2481146 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag MTP23_RS12295 Protein ID WP_000584499.1
Coordinates 2480629..2480880 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP23_RS12265 (2476327) 2476327..2477046 + 720 WP_000479576.1 amino acid ABC transporter permease -
MTP23_RS12270 (2477043) 2477043..2477774 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
MTP23_RS12275 (2477871) 2477871..2479121 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
MTP23_RS12280 (2479376) 2479376..2479738 + 363 WP_000819843.1 DUF4467 domain-containing protein -
MTP23_RS12285 (2479757) 2479757..2480356 + 600 WP_000162810.1 DsbA family protein -
MTP23_RS12290 (2480384) 2480384..2480464 + 81 WP_223197974.1 hypothetical protein -
MTP23_RS12295 (2480629) 2480629..2480880 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTP23_RS12300 (2480880) 2480880..2481146 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
MTP23_RS12305 (2481181) 2481181..2481252 + 72 Protein_2398 hypothetical protein -
MTP23_RS12310 (2481441) 2481441..2482988 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
MTP23_RS12315 (2483174) 2483174..2483641 + 468 WP_000153347.1 SRPBCC domain-containing protein -
MTP23_RS12320 (2483725) 2483725..2483907 + 183 WP_000230292.1 hypothetical protein -
MTP23_RS12325 (2484124) 2484124..2484948 + 825 WP_000572038.1 formate/nitrite transporter family protein -
MTP23_RS12330 (2485182) 2485182..2485718 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T239821 WP_000113265.1 NZ_CP094443:2480880-2481146 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T239821 NZ_LS483345:1540639-1540974 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGAGGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT239821 WP_000584499.1 NZ_CP094443:2480629-2480880 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT239821 NZ_LS483345:1540362-1540649 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGAGCTGAACTTGGACTATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References