Detailed information of TA system TA239819

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2455467..2455651
• Replicon: chromosome
• Accession: NZ_CP094443
• Organism: Staphylococcus aureus strain N10CSA27

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: MTP23_RS12165
• Protein ID: WP_000482652.1
• Coordinates: 2455467..2455574 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2455591..2455651 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP23_RS12140	2450829..2451302	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
MTP23_RS12145	2451425..2452636	-	1212	WP_001192073.1	multidrug effflux MFS transporter	-
MTP23_RS12150	2452818..2453477	-	660	WP_000831298.1	membrane protein	-
MTP23_RS12155	2453537..2454679	-	1143	WP_001176863.1	glycerate kinase	-
MTP23_RS12160	2454947..2455333	+	387	WP_000779360.1	flippase GtxA	-
MTP23_RS12165	2455467..2455574	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2455591..2455651	-	61	-	-	Antitoxin
MTP23_RS12170	2456277..2458040	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
MTP23_RS12175	2458065..2459798	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
MTP23_RS12180	2460065..2460196	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T239819 WP_000482652.1 NZ_CP094443:2455467-2455574 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T239819 NZ_LS483343:179494-179826 [Streptococcus ferus]
ATGGTAAGTATTAAGCAAGGGTCTATCATTAAAATTAACCTTGACCCTAAACAAGGTCATGAACAAAAAGGTTATCGCCC
TTATATTTGTTTAAGTCATAGCGTTGTTACGAAGTATTCTAACCTTGCTATTTTTGCCCCTGTTAGCAATACCAAAAGAG
ATTACCCCTTTTATGTCCCTCTGAGAGATACTGAAACAACTGGTAAAGTCTTACTTGACCAGTTGGTGACAATAGATTTC
AATGCTAGAGATTATCGGTATATAGAAGATGTTTCAGACGAGTTATTGATTAGCTTGCTAGCTCGTGTGAAAGTATTGTT
TGAAAAGGGATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT239819 NZ_CP094443:c2455651-2455591 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin