Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1221081..1221495 Replicon chromosome
Accession NZ_CP094443
Organism Staphylococcus aureus strain N10CSA27

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MTP23_RS06185 Protein ID WP_025174939.1
Coordinates 1221244..1221495 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MTP23_RS06180 Protein ID WP_000028424.1
Coordinates 1221081..1221254 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP23_RS06135 (1216886) 1216886..1218094 - 1209 WP_001606760.1 PBSX family phage terminase large subunit -
MTP23_RS06140 (1218087) 1218087..1218581 - 495 WP_000594085.1 hypothetical protein -
MTP23_RS06145 (1218932) 1218932..1219333 - 402 WP_000286968.1 hypothetical protein -
MTP23_RS06150 (1219445) 1219445..1219549 - 105 Protein_1186 hypothetical protein -
MTP23_RS06155 (1219542) 1219542..1219778 - 237 WP_000608278.1 hypothetical protein -
MTP23_RS06160 (1219771) 1219771..1220058 - 288 WP_000195801.1 DUF1381 domain-containing protein -
MTP23_RS06165 (1220095) 1220095..1220622 - 528 WP_107364916.1 dUTPase -
MTP23_RS06170 (1220637) 1220637..1220798 - 162 WP_000889683.1 hypothetical protein -
MTP23_RS06175 (1220799) 1220799..1221080 - 282 WP_000454994.1 hypothetical protein -
MTP23_RS06180 (1221081) 1221081..1221254 - 174 WP_000028424.1 hypothetical protein Antitoxin
MTP23_RS06185 (1221244) 1221244..1221495 - 252 WP_025174939.1 DUF1024 family protein Toxin
MTP23_RS06190 (1221510) 1221510..1221758 - 249 WP_031903705.1 phi PVL orf 51-like protein -
MTP23_RS06195 (1221759) 1221759..1222130 - 372 WP_001140289.1 SA1788 family PVL leukocidin-associated protein -
MTP23_RS06200 (1222131) 1222131..1222316 - 186 WP_001187242.1 DUF3113 family protein -
MTP23_RS06205 (1222321) 1222321..1222725 - 405 WP_000049784.1 DUF1064 domain-containing protein -
MTP23_RS06210 (1222736) 1222736..1222957 - 222 WP_001123673.1 DUF3269 family protein -
MTP23_RS06215 (1222970) 1222970..1223131 - 162 WP_000237153.1 hypothetical protein -
MTP23_RS06220 (1223125) 1223125..1223904 - 780 WP_000803065.1 ATP-binding protein -
MTP23_RS06225 (1223914) 1223914..1224684 - 771 WP_000190224.1 conserved phage C-terminal domain-containing protein -
MTP23_RS06230 (1224749) 1224749..1225606 + 858 WP_000371250.1 DUF4393 domain-containing protein -
MTP23_RS06235 (1225712) 1225712..1226386 - 675 WP_243616920.1 putative HNHc nuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1186998..1236411 49413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T239816 WP_025174939.1 NZ_CP094443:c1221495-1221244 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T239816 NZ_LS483340:1571379-1571714 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGAGGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT239816 WP_000028424.1 NZ_CP094443:c1221254-1221081 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT239816 NZ_LS483340:1571102-1571389 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGAGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References