Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) TMCS/-
Location 508799..509378 Replicon chromosome
Accession NZ_CP094443
Organism Staphylococcus aureus strain N10CSA27

Toxin (Protein)


Gene name MW1434 Uniprot ID A0A4P7P609
Locus tag MTP23_RS02745 Protein ID WP_001025401.1
Coordinates 508799..509044 (+) Length 82 a.a.

Antitoxin (RNA)


Gene name MW1433
Locus tag -
Coordinates 509013..509378 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTP23_RS02705 (503885) 503885..505090 - 1206 WP_000264751.1 site-specific integrase -
MTP23_RS02710 (505216) 505216..505830 + 615 WP_000191470.1 hypothetical protein -
MTP23_RS02715 (505827) 505827..505973 - 147 WP_001795334.1 hypothetical protein -
MTP23_RS02720 (506203) 506203..506787 - 585 WP_000825949.1 hypothetical protein -
MTP23_RS02725 (506805) 506805..507266 - 462 WP_000525004.1 hypothetical protein -
MTP23_RS02730 (507279) 507279..507593 - 315 WP_000333631.1 helix-turn-helix transcriptional regulator -
MTP23_RS02735 (507745) 507745..507975 + 231 WP_001661993.1 helix-turn-helix transcriptional regulator -
MTP23_RS02740 (507994) 507994..508770 + 777 WP_001148544.1 Rha family transcriptional regulator -
MTP23_RS02745 (508799) 508799..509044 + 246 WP_001025401.1 DUF2829 domain-containing protein Toxin
MTP23_RS02750 (509013) 509013..509378 - 366 WP_001128433.1 hypothetical protein Antitoxin
MTP23_RS02755 (509433) 509433..509648 + 216 WP_001097552.1 hypothetical protein -
MTP23_RS02760 (509675) 509675..509938 + 264 WP_001124194.1 helix-turn-helix domain-containing protein -
MTP23_RS02765 (509951) 509951..510112 + 162 WP_001285948.1 DUF1270 domain-containing protein -
MTP23_RS02770 (510191) 510191..510514 + 324 WP_000174999.1 hypothetical protein -
MTP23_RS02775 (510529) 510529..510891 + 363 WP_000985972.1 hypothetical protein -
MTP23_RS02780 (510888) 510888..512054 + 1167 WP_000762552.1 DUF2800 domain-containing protein -
MTP23_RS02785 (512080) 512080..512637 + 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-69)


Sequences


Toxin        


Download         Length: 82 a.a.        Molecular weight: 9468.72 Da        Isoelectric Point: 5.7783

>T239813 WP_001025401.1 NZ_CP094443:508799-509044 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Download         Length: 246 bp

>T239813 NZ_LS483335:1672021-1672356 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 366 bp

>AT239813 NZ_CP094443:c509378-509013 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4P7P609


Antitoxin

Download structure file

References