Detailed information of TA system TA239810

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 174771..174951
• Replicon: chromosome
• Accession: NZ_CP094443
• Organism: Staphylococcus aureus strain N10CSA27

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: MTP23_RS01095
• Protein ID: WP_001801861.1
• Coordinates: 174856..174951 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	174771..174828 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTP23_RS01065	170480..170614	+	135	WP_001791797.1	hypothetical protein	-
MTP23_RS01070	170778..172334	+	1557	WP_000028669.1	type I restriction-modification system subunit M	-
MTP23_RS01075	172327..173556	+	1230	WP_000072627.1	restriction endonuclease subunit S	-
MTP23_RS01080	174098..174508	+	411	WP_001808705.1	IS21 family transposase	-
MTP23_RS01085	174493..174654	+	162	Protein_178	transposase	-
MTP23_RS01090	174632..174733	-	102	WP_001792025.1	hypothetical protein	-
-	174771..174828	+	58	-	-	Antitoxin
MTP23_RS01095	174856..174951	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
MTP23_RS01100	175096..176108	+	1013	Protein_181	IS3 family transposase	-
MTP23_RS01105	176306..176878	-	573	WP_000414216.1	hypothetical protein	-
MTP23_RS01110	176979..177320	-	342	WP_000627540.1	DUF3969 family protein	-
MTP23_RS01115	177361..177987	-	627	WP_000669024.1	hypothetical protein	-
MTP23_RS01120	178062..179057	-	996	WP_000070642.1	DUF4352 domain-containing protein	-
MTP23_RS01125	179138..179788	-	651	WP_001838777.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	147938..198968	51030

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T239810 WP_001801861.1 NZ_CP094443:c174951-174856 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T239810 NZ_LS483332:1602020-1602355 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTATCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT239810 NZ_CP094443:174771-174828 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin