Detailed information of TA system TA239775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1390261..1390838
• Replicon: chromosome
• Accession: NZ_CP094359
• Organism: Acidithiobacillus sp. YTS05

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MQE22_RS06870
• Protein ID: WP_255789406.1
• Coordinates: 1390560..1390838 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: MQE22_RS06865
• Protein ID: WP_255789405.1
• Coordinates: 1390261..1390560 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE22_RS06855 (MQE22_06855)	1386288..1387292	-	1005	WP_255789403.1	hypothetical protein	-
MQE22_RS06860 (MQE22_06860)	1387417..1390176	-	2760	WP_255789404.1	lactate dehydrogenase	-
MQE22_RS06865 (MQE22_06865)	1390261..1390560	-	300	WP_255789405.1	HigA family addiction module antitoxin	Antitoxin
MQE22_RS06870 (MQE22_06870)	1390560..1390838	-	279	WP_255789406.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQE22_RS06875 (MQE22_06875)	1391042..1393903	+	2862	WP_255789407.1	MobF family relaxase	-
MQE22_RS06880 (MQE22_06880)	1394289..1394600	+	312	WP_255789408.1	hypothetical protein	-
MQE22_RS06885 (MQE22_06885)	1394612..1395328	+	717	WP_255789409.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1379398..1412687	33289

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-85)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10533.96 Da
• Isoelectric Point: 8.5481

>T239775 WP_255789406.1 NZ_CP094359:c1390838-1390560 [Acidithiobacillus sp. YTS05]
MIRSFRHKGLEAFYASGSLAGIQAQHAKRLRMLLAALDTAQAIGDMDIPGFRLHPLQGTEKGRWSIRVNANWRLTFDFQD
GHAYVLDYEDYH

Nucleotide

• Length: 279 bp

>T239775 NZ_LS483317:c1967603-1967451 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATTTCTGATCAAAATGATCAAGAAAAGAATTCAGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11112.61 Da
• Isoelectric Point: 6.7239

>AT239775 WP_255789405.1 NZ_CP094359:c1390560-1390261 [Acidithiobacillus sp. YTS05]
MEMHNPPHPGEFIREVYLEPNGITGRQLATKLGVSASTLARVLNGSNGVSSEMALRLSKALGRSAESWMIMQDHFDLWQA
RQRVNLDQVQRLDLQPADQ

Nucleotide

• Length: 300 bp

>AT239775 NZ_LS483317:c1968228-1967629 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACTGATCAAGCGCCAGTACTAGATGAATTAAAGAAAAATATTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACTGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA