Detailed information of TA system TA239770

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 2712868..2713461
• Replicon: chromosome
• Accession: NZ_CP094358
• Organism: Abyssalbus ytuae strain MT3330

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: MQE35_RS11495
• Protein ID: WP_255841531.1
• Coordinates: 2712868..2713149 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MQE35_RS11500
• Protein ID: WP_255841532.1
• Coordinates: 2713162..2713461 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQE35_RS11480 (MQE35_11460)	2708143..2710458	+	2316	WP_255841529.1	prolyl oligopeptidase family serine peptidase	-
MQE35_RS11485 (MQE35_11465)	2710764..2711822	+	1059	WP_255841530.1	histidine kinase	-
MQE35_RS11490 (MQE35_11470)	2711816..2712544	+	729	WP_255846111.1	LytTR family DNA-binding domain-containing protein	-
MQE35_RS11495 (MQE35_11475)	2712868..2713149	+	282	WP_255841531.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQE35_RS11500 (MQE35_11480)	2713162..2713461	+	300	WP_255841532.1	HigA family addiction module antitoxin	Antitoxin
MQE35_RS11505 (MQE35_11485)	2713635..2714249	-	615	WP_255841533.1	JAB domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (2-93)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-97)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10997.63 Da
• Isoelectric Point: 10.6238

>T239770 WP_255841531.1 NZ_CP094358:2712868-2713149 [Abyssalbus ytuae]
VIKSFGGKETEEIWNGTQSKKLPADIQNVARRKLRMINNAQNINDLRIPPANRLEKLSGNLKKYYSIQINKRWRIIFIWN
NDNAFEVQIVDYH

Nucleotide

• Length: 282 bp

>T239770 NZ_LS483316:c2580266-2580000 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11420.14 Da
• Isoelectric Point: 9.5154

>AT239770 WP_255841532.1 NZ_CP094358:2713162-2713461 [Abyssalbus ytuae]
MKKLKNIHPGEILKEEFLDPLNITAYRLSKDTFIPQTRVSEIIKGNRRITADTALRLSKYFGTTAKFWLGLQDDFDLEEE
KNIKGKELNNIKPIENNAA

Nucleotide

• Length: 300 bp

>AT239770 NZ_LS483316:c2580523-2580266 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA