Detailed information of TA system TA239760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1119921..1120443
• Replicon: chromosome
• Accession: NZ_CP094348
• Organism: Macrococcus armenti strain CCM 2609

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MRZ06_RS05830
• Protein ID: WP_243364988.1
• Coordinates: 1119921..1120193 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MRZ06_RS05835
• Protein ID: WP_243364989.1
• Coordinates: 1120186..1120443 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRZ06_RS05795 (MRZ06_05790)	1115342..1115848	+	507	WP_243364984.1	carboxymuconolactone decarboxylase family protein	-
MRZ06_RS05800 (MRZ06_05795)	1116980..1117231	+	252	WP_086042489.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MRZ06_RS05805 (MRZ06_05800)	1117231..1117491	+	261	WP_133418826.1	Txe/YoeB family addiction module toxin	-
MRZ06_RS05810 (MRZ06_05805)	1117492..1117941	-	450	WP_224202679.1	GNAT family N-acetyltransferase	-
MRZ06_RS05815 (MRZ06_05810)	1118308..1118460	+	153	WP_243364985.1	hypothetical protein	-
MRZ06_RS05820 (MRZ06_05815)	1118646..1119131	+	486	WP_243364986.1	NUDIX domain-containing protein	-
MRZ06_RS05825 (MRZ06_05820)	1119137..1119898	+	762	WP_243364987.1	hypothetical protein	-
MRZ06_RS05830 (MRZ06_05825)	1119921..1120193	-	273	WP_243364988.1	Txe/YoeB family addiction module toxin	Toxin
MRZ06_RS05835 (MRZ06_05830)	1120186..1120443	-	258	WP_243364989.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MRZ06_RS05840 (MRZ06_05835)	1120715..1121245	+	531	WP_243364990.1	GrpB family protein	-
MRZ06_RS05845 (MRZ06_05840)	1121530..1123143	+	1614	WP_243364991.1	ABC-F type ribosomal protection protein	-
MRZ06_RS05850 (MRZ06_05845)	1123483..1124745	+	1263	WP_243364992.1	Y-family DNA polymerase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10595.32 Da
• Isoelectric Point: 9.5657

>T239760 WP_243364988.1 NZ_CP094348:c1120193-1119921 [Macrococcus armenti]
MPKKKILFYSGGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCSFHYKR

Nucleotide

• Length: 273 bp

>T239760 NZ_LS483315:1570838-1571173 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9708.81 Da
• Isoelectric Point: 4.1540

>AT239760 WP_243364989.1 NZ_CP094348:c1120443-1120186 [Macrococcus armenti]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLPKTIDESIDKNNLLQVE
IDLDA

Nucleotide

• Length: 258 bp

>AT239760 NZ_LS483315:1570561-1570848 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA