Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1119921..1120443 Replicon chromosome
Accession NZ_CP094348
Organism Macrococcus armenti strain CCM 2609

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag MRZ06_RS05830 Protein ID WP_243364988.1
Coordinates 1119921..1120193 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MRZ06_RS05835 Protein ID WP_243364989.1
Coordinates 1120186..1120443 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MRZ06_RS05795 (MRZ06_05790) 1115342..1115848 + 507 WP_243364984.1 carboxymuconolactone decarboxylase family protein -
MRZ06_RS05800 (MRZ06_05795) 1116980..1117231 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
MRZ06_RS05805 (MRZ06_05800) 1117231..1117491 + 261 WP_133418826.1 Txe/YoeB family addiction module toxin -
MRZ06_RS05810 (MRZ06_05805) 1117492..1117941 - 450 WP_224202679.1 GNAT family N-acetyltransferase -
MRZ06_RS05815 (MRZ06_05810) 1118308..1118460 + 153 WP_243364985.1 hypothetical protein -
MRZ06_RS05820 (MRZ06_05815) 1118646..1119131 + 486 WP_243364986.1 NUDIX domain-containing protein -
MRZ06_RS05825 (MRZ06_05820) 1119137..1119898 + 762 WP_243364987.1 hypothetical protein -
MRZ06_RS05830 (MRZ06_05825) 1119921..1120193 - 273 WP_243364988.1 Txe/YoeB family addiction module toxin Toxin
MRZ06_RS05835 (MRZ06_05830) 1120186..1120443 - 258 WP_243364989.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MRZ06_RS05840 (MRZ06_05835) 1120715..1121245 + 531 WP_243364990.1 GrpB family protein -
MRZ06_RS05845 (MRZ06_05840) 1121530..1123143 + 1614 WP_243364991.1 ABC-F type ribosomal protection protein -
MRZ06_RS05850 (MRZ06_05845) 1123483..1124745 + 1263 WP_243364992.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10595.32 Da        Isoelectric Point: 9.5657

>T239760 WP_243364988.1 NZ_CP094348:c1120193-1119921 [Macrococcus armenti]
MPKKKILFYSGGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCSFHYKR

Download         Length: 273 bp

>T239760 NZ_LS483315:1570838-1571173 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTACTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGCTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9708.81 Da        Isoelectric Point: 4.1540

>AT239760 WP_243364989.1 NZ_CP094348:c1120443-1120186 [Macrococcus armenti]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLPKTIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT239760 NZ_LS483315:1570561-1570848 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGACGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References