Detailed information of TA system TA239759

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe(toxin)
• Location: 1116980..1117491
• Replicon: chromosome
• Accession: NZ_CP094348
• Organism: Macrococcus armenti strain CCM 2609

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: MRZ06_RS05805
• Protein ID: WP_133418826.1
• Coordinates: 1117231..1117491 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: MRZ06_RS05800
• Protein ID: WP_086042489.1
• Coordinates: 1116980..1117231 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MRZ06_RS05780 (MRZ06_05775)	1112658..1113791	+	1134	WP_243364981.1	phosphoribosyltransferase	-
MRZ06_RS05785 (MRZ06_05780)	1114136..1114636	-	501	WP_243364982.1	phosphoribosylanthranilate isomerase	-
MRZ06_RS05790 (MRZ06_05785)	1114659..1115213	-	555	WP_243364983.1	TetR/AcrR family transcriptional regulator	-
MRZ06_RS05795 (MRZ06_05790)	1115342..1115848	+	507	WP_243364984.1	carboxymuconolactone decarboxylase family protein	-
MRZ06_RS05800 (MRZ06_05795)	1116980..1117231	+	252	WP_086042489.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MRZ06_RS05805 (MRZ06_05800)	1117231..1117491	+	261	WP_133418826.1	Txe/YoeB family addiction module toxin	Toxin
MRZ06_RS05810 (MRZ06_05805)	1117492..1117941	-	450	WP_224202679.1	GNAT family N-acetyltransferase	-
MRZ06_RS05815 (MRZ06_05810)	1118308..1118460	+	153	WP_243364985.1	hypothetical protein	-
MRZ06_RS05820 (MRZ06_05815)	1118646..1119131	+	486	WP_243364986.1	NUDIX domain-containing protein	-
MRZ06_RS05825 (MRZ06_05820)	1119137..1119898	+	762	WP_243364987.1	hypothetical protein	-
MRZ06_RS05830 (MRZ06_05825)	1119921..1120193	-	273	WP_243364988.1	Txe/YoeB family addiction module toxin	-
MRZ06_RS05835 (MRZ06_05830)	1120186..1120443	-	258	WP_243364989.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
MRZ06_RS05840 (MRZ06_05835)	1120715..1121245	+	531	WP_243364990.1	GrpB family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (21-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-59)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10287.92 Da
• Isoelectric Point: 10.1614

>T239759 WP_133418826.1 NZ_CP094348:1117231-1117491 [Macrococcus armenti]
MYKIVMKSSVKKDLKKIKNTHLETNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEDKIVTIYS
AYGHYE

Nucleotide

• Length: 261 bp

>T239759 NZ_LS483314:c2491980-2491738 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCGGCGAAGTTAGATTTAAAGAAGACATTTATAGAAATTGTTGAGACTTT
AAAAAATAATCCTTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATTTAGAGCGATATTCAAGAAGAATTA
ACCTTCAGCACAGGGTCGTCTATACCATAGATGATCGAAATAAAGTAGTATTAATACTATCGGCATGGTCACATTATGAT
TAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9590.65 Da
• Isoelectric Point: 4.0373

>AT239759 WP_086042489.1 NZ_CP094348:1116980-1117231 [Macrococcus armenti]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Nucleotide

• Length: 252 bp

>AT239759 NZ_LS483314:c2492237-2491980 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGTAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATGT
ATCTTGTATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA