Detailed information of TA system TA239744

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1092872..1093572
• Replicon: chromosome
• Accession: NZ_CP094343
• Organism: Pseudomonas sp. M1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: W5IYY9
• Locus tag: PM1_RS04915
• Protein ID: WP_009615994.1
• Coordinates: 1092872..1093168 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: W5IWV4
• Locus tag: PM1_RS04920
• Protein ID: WP_009615995.1
• Coordinates: 1093171..1093572 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PM1_RS04885 (MRY70_04885)	1089118..1090002	-	885	WP_009615988.1	methylisocitrate lyase	-
PM1_RS04890 (MRY70_04890)	1089999..1090721	-	723	WP_009615989.1	GntR family transcriptional regulator	-
PM1_RS04895 (MRY70_04895)	1090917..1091528	+	612	WP_009615990.1	class I SAM-dependent methyltransferase	-
PM1_RS04900 (MRY70_04900)	1091536..1091775	-	240	WP_009615991.1	hypothetical protein	-
PM1_RS04905 (MRY70_04905)	1091951..1092181	-	231	WP_009615992.1	hypothetical protein	-
PM1_RS04910 (MRY70_04910)	1092293..1092745	-	453	WP_009615993.1	hypothetical protein	-
PM1_RS04915 (MRY70_04915)	1092872..1093168	+	297	WP_009615994.1	type II toxin-antitoxin system MqsR family toxin	Toxin
PM1_RS04920 (MRY70_04920)	1093171..1093572	+	402	WP_009615995.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
PM1_RS04925 (MRY70_04925)	1093850..1095178	-	1329	WP_009615996.1	sigma-54 dependent transcriptional regulator	-
PM1_RS04930 (MRY70_04930)	1095175..1097061	-	1887	Protein_970	sensor histidine kinase	-
PM1_RS04935 (MRY70_04935)	1097170..1097904	-	735	WP_009615999.1	amino acid ABC transporter ATP-binding protein	-
PM1_RS04940 (MRY70_04940)	1097901..1098569	-	669	WP_173427889.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 10866.62 Da
• Isoelectric Point: 9.5238

>T239744 WP_009615994.1 NZ_CP094343:1092872-1093168 [Pseudomonas sp. M1]
MEKSTPHCRLDRVKSLLAQGRVRATYSALSGGAALGLDFAGMLAVIEALAPRDFYKSMTTHADHRVWQDVYRPSTAVGRI
YLKLTVIDDVLVVSFKEL

Nucleotide

• Length: 297 bp

>T239744 NZ_LS483311:c2512477-2512211 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14472.73 Da
• Isoelectric Point: 7.6709

>AT239744 WP_009615995.1 NZ_CP094343:1093171-1093572 [Pseudomonas sp. M1]
MKCPLCGGAELLHETRDLPYAYKGESTLITGVRGEFCPACGEAVLDADESARVNARMLAFNKRVNASMVDPGFIAAVRKK
LALDQREAAEIFGGGVNAFSRYENGKTRPPLALVKLLKVLDRHPELLEEVRAG

Nucleotide

• Length: 402 bp

>AT239744 NZ_LS483311:c2512728-2512477 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Structures

Toxin

• AlphaFold DB: W5IYY9

Antitoxin

• AlphaFold DB: W5IWV4