Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4213873..4214131 Replicon chromosome
Accession NZ_CP094339
Organism Escherichia coli strain W224N

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag MQV61_RS20770 Protein ID WP_000809168.1
Coordinates 4213979..4214131 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4213873..4213930 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQV61_RS20755 4209705..4210964 - 1260 WP_000494924.1 hypothetical protein -
MQV61_RS20760 4211093..4212586 - 1494 WP_001350775.1 sulfatase-like hydrolase/transferase -
MQV61_RS20765 4212606..4213367 - 762 WP_001274823.1 outer membrane protein OmpK -
- 4213873..4213930 - 58 - - Antitoxin
MQV61_RS20770 4213979..4214131 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
MQV61_RS20775 4214236..4215366 - 1131 WP_001118464.1 molecular chaperone DnaJ -
MQV61_RS20780 4215455..4217371 - 1917 WP_000516135.1 molecular chaperone DnaK -
MQV61_RS20785 4217743..4218147 + 405 WP_000843687.1 DUF2541 family protein -
MQV61_RS20790 4218173..4218886 + 714 WP_001102393.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T239729 WP_000809168.1 NZ_CP094339:4213979-4214131 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T239729 NZ_LS483310:c1932079-1931903 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGTTGGCATTACTGAAATCTTTAGAAAGGAGATGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 58 bp

>AT239729 NZ_CP094339:c4213930-4213873 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References