Detailed information of TA system TA239722

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hokW-rdlD/-
• Location: 2811713..2811938
• Replicon: chromosome
• Accession: NZ_CP094339
• Organism: Escherichia coli strain W224N

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: A0A8S7B7V6
• Locus tag: MQV61_RS13740
• Protein ID: WP_000813256.1
• Coordinates: 2811713..2811868 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2811880..2811938 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQV61_RS13690	2806873..2806989	+	117	Protein_2687	hypothetical protein	-
MQV61_RS13710	2807392..2808441	-	1050	WP_000935515.1	site-specific DNA-methyltransferase	-
MQV61_RS13715	2808592..2808789	-	198	WP_000917749.1	hypothetical protein	-
MQV61_RS13720	2809014..2809835	-	822	WP_000762880.1	antitermination protein	-
MQV61_RS13725	2809832..2810206	-	375	WP_000904114.1	RusA family crossover junction endodeoxyribonuclease	-
MQV61_RS13730	2810219..2811265	-	1047	WP_001265108.1	DUF968 domain-containing protein	-
MQV61_RS13735	2811267..2811545	-	279	WP_011478175.1	hypothetical protein	-
MQV61_RS13740	2811713..2811868	-	156	WP_000813256.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2811880..2811938	+	59	-	-	Antitoxin
MQV61_RS13745	2812486..2813487	-	1002	WP_000354966.1	hypothetical protein	-
MQV61_RS13750	2813503..2814465	-	963	WP_014639476.1	hypothetical protein	-
MQV61_RS13755	2814657..2815079	-	423	WP_001151216.1	DUF977 family protein	-
MQV61_RS13760	2815120..2816190	-	1071	WP_001262357.1	hypothetical protein	-
MQV61_RS13765	2816262..2816687	-	426	WP_000693867.1	toxin YdaT family protein	-
MQV61_RS13770	2816671..2816913	-	243	WP_000747951.1	Cro/CI family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2774990..2827531	52541

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5764.94 Da
• Isoelectric Point: 6.1531

>T239722 WP_000813256.1 NZ_CP094339:c2811868-2811713 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTVYEPEE

Nucleotide

• Length: 156 bp

>T239722 NZ_LS483309:c2259842-2259633 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Nucleotide

• Length: 59 bp

>AT239722 NZ_CP094339:2811880-2811938 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin